{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:28:55Z","timestamp":1754396935240,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,11,8]],"date-time":"2006-11-08T00:00:00Z","timestamp":1162944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Substance P acting via the neurokinin\u20101 receptor is involved in the development of hyperalgesia, although studies using neurokinin\u20101 receptor antagonists (NK\u20101RA) in human somatic pain have been disappointing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate whether Substance P is involved in the development of human visceral pain\/hyperalgesia using a selective NK\u20101RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a validated human model of acid\u2010induced oesophageal allodynia, pain thresholds to electrical stimulation (mA) were measured in the proximal oesophagus and the foot (somatic control), pre\u2010 and for 4\u2003h postdistal oesophageal acid in 14 healthy subjects, using a double\u2010blind, randomized, two\u2010period, crossover study. Measurements were taken on the third day of dosing with either an oral NK\u20101RA or matching placebo, with 2\u2003weeks washout between periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline pain threshold did not differ between treatments (proximal oesophagus 37\u2003\u00b1\u20037.4\u2003mA NK\u20101RA vs. 38\u2003\u00b1\u200310.1 placebo<jats:italic>P<\/jats:italic>\u2003=\u20030.81, foot 40\u2003\u00b1\u200315\u2003mA NK\u20101RA vs. 38\u2003\u00b1\u200314 placebo<jats:italic>P<\/jats:italic>\u2003=\u20030.68). NK\u20101RA did not attenuate the reduction in pain threshold in the proximal oesophagus postacid infusion (<jats:italic>AUC<\/jats:italic>\u2212394\u2003\u00b1\u2003279 NK\u20101RA vs. \u2212262\u2003\u00b1\u2003397 placebo<jats:italic>P<\/jats:italic>\u2003=\u20030.54).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The lack of effect of NK\u20101RA on oesophageal pain threshold in our model does not support a role for Substance P in the development of acid\u2010induced oesophageal allodynia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.03190.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T11:45:45Z","timestamp":1279885545000},"page":"309-316","source":"Crossref","is-referenced-by-count":20,"title":["Neurokinin\u20101 receptor antagonism in a human model of visceral hypersensitivity"],"prefix":"10.1111","volume":"25","author":[{"given":"R. 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