{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:51:06Z","timestamp":1785775866587,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,3]],"date-time":"2007-01-03T00:00:00Z","timestamp":1167782400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastro\u2010oesophageal reflux disease (GERD) patients on proton pump inhibitors before breakfast or dinner have acid recovery at night. Bedtime immediate\u2010release omeprazole (IR\u2010OME) demonstrated better control of nocturnal pH than pantoprazole before dinner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare repeated once daily bedtime dosing of IR\u2010OME, lansoprazole and esomeprazole on nocturnal gastric acidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Open\u2010label, randomized, crossover study enrolling 54 patients with nocturnal GERD symptoms comparing IR\u2010OME, lansoprazole and esomeprazole at steady state for nocturnal acid breakthrough (NAB), percentage of time with gastric pH\u2003&gt;\u20034 and median gastric pH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Onset of nocturnal acid control with IR\u2010OME was rapid. During the first half of the night, percentage of time with gastric pH\u2003&gt;\u20034 and median gastric pH were significantly higher after IR\u2010OME compared to esomeprazole or lansoprazole (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001, both comparisons). Over the 8\u2010h night\u2010time period, acid control with IR\u2010OME was significantly better than lansoprazole (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001), and comparable to esomeprazole. IR\u2010OME reduced NAB compared with esomeprazole and lansoprazole (61% vs. 92% and 92%; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001, both comparisons).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bedtime IR\u2010OME provided more rapid control of night\u2010time gastric pH and decreased NAB compared with esomeprazole and lansoprazole. Nocturnal acid control with IR\u2010OME was superior to lansoprazole and comparable to esomeprazole. Bedtime dosing with IR\u2010OME may be effective for patients with night\u2010time heartburn.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.03191.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T12:41:25Z","timestamp":1279888885000},"page":"197-205","source":"Crossref","is-referenced-by-count":82,"title":["Comparison of the effects of immediate\u2010release omeprazole oral suspension, delayed\u2010release lansoprazole capsules and delayed\u2010release esomeprazole capsules on nocturnal gastric acidity after bedtime dosing in patients with night\u2010time GERD symptoms"],"prefix":"10.1111","volume":"25","author":[{"given":"P. O.","family":"KATZ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. K.","family":"KOCH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. D.","family":"BALLARD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. G.","family":"BAGIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. C.","family":"GAUTILLE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. C.","family":"CHECANI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. L.","family":"HOGAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. S. V.","family":"PRATHA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000170762.52072.a9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/2261261a0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0800619"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02432.x"},{"key":"e_1_2_6_6_2","first-page":"11","article-title":"Nocturnal acid breakthrough \u2013 approach to management","volume":"6","author":"Tutuian R","year":"2004","journal-title":"Med Gen Med"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70025-8"},{"key":"e_1_2_6_8_2","volume-title":"A Gallup Survey of Heartburn Across America","author":"Gallup Organization","year":"1998"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07531.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.1.45"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00775.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02513.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41719.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.221_a.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03790.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00419.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)82137-X"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05532.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200323020-00001"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2006.03191.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2006.03191.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:03:22Z","timestamp":1697231002000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2006.03191.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1365-2036.2006.03191.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2006.03191.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}