{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T04:18:28Z","timestamp":1793938708655,"version":"4.8.0"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,1,8]],"date-time":"2007-01-08T00:00:00Z","timestamp":1168214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Glucagon\u2010like peptide 2 (GLP\u20102) is an important peptide growth factor secreted from the human intestine. The trophic properties of GLP\u20102 are very specific to the gut where it is pivotal in the regulation of mucosal morphology, function and integrity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This review details the current understanding of the molecular biology of GLP\u20102, its mechanisms of action and physiological properties. A major focus is the discussion of recent clinical data evaluating the use of GLP\u20102 as a therapeutic agent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Relevant articles were identified using Medline searches and from the reference lists of key papers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusions<\/jats:title><jats:p>In the treatment of short bowel syndrome, GLP\u20102 has been shown to be highly effective in improving fluid absorption. In Crohn's disease, GLP\u20102 is superior to placebo in the induction of remission. Early data also suggest that the effects of GLP\u20102 on bone metabolism can provide a new treatment approach for patients with osteoporosis. In the future, the positive effects of GLP\u20102 on intestinal barrier function, splanchnic perfusion and mucosal healing could be utilized to expand its therapeutic application to other causes of intestinal injury. However, important safety aspects need to be considered when using this potent growth\u2010promoting agent for a long term.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.03193.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T10:37:05Z","timestamp":1279881425000},"page":"365-372","source":"Crossref","is-referenced-by-count":54,"title":["Review article: glucagon\u2010like peptide 2 \u2013 current applications and future directions"],"prefix":"10.1111","volume":"25","author":[{"given":"K.","family":"WALLIS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R. 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