{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:09:42Z","timestamp":1772640582510,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T00:00:00Z","timestamp":1166745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with coeliac disease may have diarrhoea despite being on a gluten\u2010free diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess whether exocrine pancreatic insufficiency causes persisting symptoms compared with controls, we determined whether pancreatic enzyme supplementation provided symptomatic benefit in coeliac patients with chronic diarrhoea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients (<jats:italic>n<\/jats:italic>\u2003=\u2003259) were subdivided into four groups: (a) new coeliac disease (<jats:italic>n<\/jats:italic>\u2003=\u200357), (b) coeliac disease patients on a gluten\u2010free diet without gastrointestinal symptoms (<jats:italic>n<\/jats:italic>\u2003=\u200386), (c) coeliac disease patients on a gluten\u2010free diet with chronic diarrhoea (<jats:italic>n<\/jats:italic>\u2003=\u200366) and (d) patients with chronic diarrhoea without coeliac disease (<jats:italic>n<\/jats:italic>\u2003=\u200350). Stool frequency and weight, before and after treatment with pancreatic enzyme supplementation were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of a low faecal elastase\u20101 within the groups was: group (A) six of 57 (11%), group (B) five of 86 (6%), group (C) 20 of 66 (30%) and group (D) two of 50 (4%). Low faecal elastase\u20101 was more frequent in coeliac disease patients with chronic diarrhoea vs. other subgroups of coeliac disease (<jats:italic>P<\/jats:italic>\u2003\u2264\u20030.0001) and controls (<jats:italic>P<\/jats:italic>\u2003\u2264\u20030.0003). In 18 of 20 stool frequency reduced following pancreatic enzyme supplementation from four per day to one (<jats:italic>P<\/jats:italic>\u2003\u2264\u20030.001). No weight increase (<jats:italic>P<\/jats:italic>\u2003=\u20030.3) was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low faecal elastase is common in patients with coeliac disease and chronic diarrhoea, suggesting exocrine pancreatic insufficiency. In this group of patients, pancreatic enzyme supplementation may provide symptomatic benefit.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.03206.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T12:45:50Z","timestamp":1279889150000},"page":"265-271","source":"Crossref","is-referenced-by-count":76,"title":["Is exocrine pancreatic insufficiency in adult coeliac disease a cause of persisting symptoms?"],"prefix":"10.1111","volume":"25","author":[{"given":"J. S.","family":"LEEDS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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