{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:43:59Z","timestamp":1775094239204,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,12,7]],"date-time":"2006-12-07T00:00:00Z","timestamp":1165449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The use of non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs) is often associated with upper gastrointestinal symptoms such as heartburn and acid regurgitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the efficacy of esomeprazole 20 and 40\u2003mg for resolution of heartburn and acid regurgitation in continuous NSAIDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A <jats:italic>post hoc<\/jats:italic> analysis of five clinical trials was performed. Two identically designed, placebo\u2010controlled, 4\u2010week studies (NASA1, SPACE1) enrolled non\u2010ulcer, NSAIDs\u2010treated patients with upper abdominal pain, discomfort or burning. PLUTO and VENUS were identically designed, placebo\u2010controlled, 6\u2010month studies that enrolled patients at risk of NSAIDs\u2010induced ulcers. Study 285 was an 8\u2010week comparative study with ranitidine (300\u2003mg\/day) in patients with NSAIDs\u2010induced gastric ulcers. Resolution of investigator\u2010assessed heartburn and acid regurgitation was defined as symptom severity of \u2018none\u2019 in the last 7\u2003days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In NASA1\/SPACE1, heartburn resolved in 61% and 62% of patients taking esomeprazole 20 and 40\u2003mg, respectively (vs. 36% on placebo, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001), and acid regurgitation resolved in 65% and 67% (vs. 48%, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Resolution of both symptoms was greater with esomeprazole than with placebo in PLUTO\/VENUS (<jats:italic>P<\/jats:italic>\u2003\u2264\u20030.001), and than with ranitidine in study 285 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05 for esomeprazole 20\u2003mg).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Heartburn and regurgitation are common in patients taking NSAIDs and esomeprazole is efficacious for resolution of these symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.03210.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T12:46:31Z","timestamp":1279889191000},"page":"813-821","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy of esomeprazole for resolution of symptoms of heartburn and acid regurgitation in continuous users of non\u2010steroidal anti\u2010inflammatory drugs"],"prefix":"10.1111","volume":"25","author":[{"given":"C. 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