{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:56:41Z","timestamp":1778504201324,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T00:00:00Z","timestamp":1166572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The incidence rates of gastric and oesophageal adenocarcinoma are changing significantly, but little is known about specific sub\u2010sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To use a population\u2010based approach to describe the trends in the site\u2010specific incidence of oesophageal and gastric adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Rochester Epidemiology Project, all cases of gastric and oesophageal adenocarcinoma among Olmsted County, Minnesota, residents first diagnosed between 1971 and 2000 were identified (<jats:italic>n<\/jats:italic>\u2003=\u2003186). Complete in\u2010patient and out\u2010patient records were reviewed and site determined from pathological, surgical, endoscopic and radiological reports.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between the decades of 1971\u20131980 and 1991\u20132000, the incidence of oesophageal adenocarcinoma increased significantly from 0.4 to 2.5 per 100\u2003000 person\u2010years. The incidence of adenocarcinoma of the oesophagogastric junction also increased from a rate of 0.6 to 2.2 per 100\u2003000 person\u2010years. The incidence rate of cancer involving the gastric cardia was stable but the incidence of adenocarcinoma involving distal gastric sites declined. Combined oesophageal and oesophagogastric junction adenocarcinoma (4.7 per 1\u2003000\u2003000 person\u2010years) was as common as gastric adenocarcinoma (3.4 per 100\u2003000 person\u2010years) in 1991\u20132000.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence rates of adenocarcinoma involving proximal gastric sub\u2010sites do not appear to be increasing in a manner similar to those involving oesophageal sub\u2010sites.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.03229.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T12:39:43Z","timestamp":1279888783000},"page":"447-453","source":"Crossref","is-referenced-by-count":43,"title":["The changing incidence of oesophageal and gastric adenocarcinoma by anatomic sub\u2010site"],"prefix":"10.1111","volume":"25","author":[{"given":"S. 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