{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:27:23Z","timestamp":1762176443573},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T00:00:00Z","timestamp":1166659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Two\u2010thirds of proton pump inhibitor prescribing in the UK is for long\u2010term therapy.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To determine the impact of eradication in long\u2010term proton pump inhibitor users infected with <jats:italic>Helicobacter pylori<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A total of 184 <jats:italic>H. pylori<\/jats:italic>\u2010positive patients were randomly assigned to true or placebo eradication therapy. The primary outcome was the change in proton pump inhibitor usage measured by prescriptions; secondary outcomes were changes of proton pump inhibitor doses, dyspepsia symptoms, general practitioner consultations and quality of life measures.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In the year following <jats:italic>H. pylori<\/jats:italic> eradication proton pump inhibitor prescriptions fell compared with placebo (\u22121.7, 95% CI: \u22122.3 to \u22121.1, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001); when adjusted to full\u2010dose equivalent prescriptions the reduction was more marked (\u22122.2, 95% CI: \u22123.0 to \u22121.4, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Both general practitioner consultations (\u22121.0, 95% CI: \u22121.8 to \u22120.1, <jats:italic>P<\/jats:italic>\u2003=\u20030.026) and symptoms measured on the Leeds Dyspepsia Questionnaire (\u22123.1, 95% CI: \u22125.3 to \u22120.9, <jats:italic>P<\/jats:italic>\u2003=\u20030.005) were reduced. Quality of life and self\u2010rating measures also favoured eradication (EQ\u20105D: 0.09, <jats:italic>P<\/jats:italic>\u2003=\u20030.08 and VAS: 5.6, <jats:italic>P<\/jats:italic>\u2003=\u20030.002). The Carlsson and Dent Reflux Questionnaire found no difference between groups (\u22120.3, <jats:italic>P<\/jats:italic>\u2003=\u20030.65), possibly balancing decreased overall symptoms with increased prominence of heartburn in the eradication group.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>  <jats:italic>Helicobacter pylori<\/jats:italic> eradication in infected, long\u2010term proton pump inhibitor users in primary care reduced both the overall severity of symptoms and use of health care.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.03234.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T12:50:35Z","timestamp":1279889435000},"page":"585-592","source":"Crossref","is-referenced-by-count":9,"title":["Helicobacter pylori eradication in long\u2010term proton pump inhibitor users in primary care: a randomized\u2010controlled trial"],"prefix":"10.1111","volume":"25","author":[{"given":"A. 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