{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:44:56Z","timestamp":1792604696482,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T00:00:00Z","timestamp":1166659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> To assess the relationship between the percentage of time intragastric pH &gt;4.0 and healing of erosive oesophagitis.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In this proof\u2010of\u2010concept study, adults with endoscopically verified Los Angeles grade C or grade D erosive oesophagitis were randomly assigned to oral esomeprazole 10 or 40\u2003mg once daily for 4\u2003weeks. On day 5, patients underwent 24\u2010h pH monitoring. At 4\u2003weeks, erosive oesophagitis healing status was endoscopically assessed. Investigators scored gastro\u2010oesophageal reflux disease symptoms on a 4\u2010point scale [none to severe (0\u20133)] before and 4\u2003weeks after treatment. The percentage of time intragastric pH was &gt;4.0 and healing status were correlated and tested for significance using a Spearman rank correlation (<jats:italic>r<\/jats:italic>).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> 103 patients had evaluable data (mean age, 48.7\u2003years; 65% men). Mean percentages of time with intragastric pH &gt;4.0 on day 5 in patients with healed and unhealed erosive oesophagitis were 61% and 42%, respectively (<jats:italic>P<\/jats:italic>\u2003=\u20030.0002), indicating that erosive oesophagitis healing rates were positively related to the percentage of time intragastric pH was &gt;4.0. Greater intragastric acid control correlated with lower final daytime and night\u2010time heartburn and acid regurgitation symptom scores (<jats:italic>r<\/jats:italic>\u2003=\u2003\u22120.029, \u22120.029 and \u22120.021; <jats:italic>P<\/jats:italic>\u2003=\u20030.003, 0.003 and 0.032, respectively).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> A positive relationship between intragastric acid control and erosive oesophagitis healing was demonstrated.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.03235.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T12:40:56Z","timestamp":1279888856000},"page":"617-628","source":"Crossref","is-referenced-by-count":70,"title":["Relationship between intragastric acid control and healing status in the treatment of moderate to severe erosive oesophagitis"],"prefix":"10.1111","volume":"25","author":[{"given":"P. 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