{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:50:59Z","timestamp":1785775859699,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,1,8]],"date-time":"2007-01-08T00:00:00Z","timestamp":1168214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Acid exposure of proximal oesophagus and dilated intercellular space diameters of oesophageal epithelium are relevant in the perception of gastro\u2010oesophageal reflux.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To explain the relationship between gastro\u2010oesophageal reflux disease symptoms, acid exposure and intercellular space diameter along the oesophageal epithelium and to assess time\u2010related variability of intercellular space diameter.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Thirty\u2010three non\u2010erosive reflux disease (NERD), six erosive oesophagitis patients and 12 asymptomatic controls underwent oesophageal manometry and 24\u2010h dual\u2010channel oesophageal pH\u2010monitoring following endoscopy. Biopsies were taken 5\u2003cm above the LES and 10\u2003cm below the UES, at comparable levels, as pH sensors. A total of 100 intercellular space diameters per patient\/control were measured blindly at transmission electron microscopy. In 15 patients, the investigation was repeated after 1\u2003year.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In all NERD patients, acid exposure was higher at mid\u2010proximal oesophagus (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01) and mean intercellular space diameters, at distal and mid\u2010proximal oesophagus, was three\u2010 and twofold higher (1.5 and 0.82\u2003<jats:italic>\u03bc<\/jats:italic>m, respectively) compared with controls. Intra\u2010patient intercellular space diameter values were stable over time, not overlapping with those of controls.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Dilation of intercellular space diameter occurs along the distal and proximal oesophageal epithelium in NERD patients and could be responsible for the enhanced perception of proximal acid reflux. This finding appears to be time\u2010reproducible and to represent a sensitive, histopathological marker of NERD.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.03237.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T10:35:48Z","timestamp":1279881348000},"page":"629-636","source":"Crossref","is-referenced-by-count":101,"title":["Dilated intercellular spaces and acid reflux at the distal and proximal oesophagus in patients with non\u2010erosive gastro\u2010oesophageal reflux disease"],"prefix":"10.1111","volume":"25","author":[{"given":"R.","family":"CAVIGLIA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"RIBOLSI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"GENTILE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"RABITTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"EMERENZIANI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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