{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:59:54Z","timestamp":1761807594105},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,3,16]],"date-time":"2007-03-16T00:00:00Z","timestamp":1174003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> No studies have examined the risk of upper gastrointestinal diseases among patients with unexplained chest\/epigastric pain (UCEP) and a normal upper endoscopy.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To examine the relative risk of peptic ulcer, oesophagitis, pancreatitis or gallstone in UCEP patients.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> This Danish 10\u2010year cohort study focused on UCEP patients (<jats:italic>n<\/jats:italic>\u2003=\u2003386), diagnosed in 1992\u201393. Ten age\u2010 and gender\u2010matched controls were selected per patient from Denmark\u2019s Civil Registration System (<jats:italic>n<\/jats:italic>\u2003=\u20033860). Kaplan\u2013Meier analysis and Cox\u2019s regression analysis was used to calculate the risk of hospitalization for peptic ulcer, oesophagitis, pancreatitis or gallstone.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Compared with controls, the adjusted relative risks among UCEP patients &lt;1 and \u22651\u2003year after upper endoscopy were for peptic ulcer 2.0 [95% confidence interval (CI) 0.2\u201318.4] and 1.7 (95% CI 0.9\u20133.4), for oesophagitis 8.2 (95% CI 1.2\u201359.2) and 1.9 (95% CI 0.7\u20135.0), for pancreatitis 9.2 (95% CI 2.0\u201341.8) and 3.9 (95% CI 1.4\u201310.5), and for gallstone 14.1 (95% CI 5.4\u201337.2) and 3.3 (95% CI 1.9\u20135.8).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> UCEP is positively associated with all study outcomes especially in the first year after upper endoscopy, indicating that peptic ulcer, oesophagitis, pancreatitis or gallstone could be underlying early UCEP symptoms. However, the long\u2010term association remained strong for pancreatitis and gallstone, suggesting a genuine excess risk.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2007.03315.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T11:32:07Z","timestamp":1279884727000},"page":"1203-1210","source":"Crossref","is-referenced-by-count":5,"title":["Risk of peptic ulcer, oesophagitis, pancreatitis or gallstone in patients with unexplained chest\/epigastric pain and normal upper endoscopy: a 10\u2010year Danish cohort study"],"prefix":"10.1111","volume":"25","author":[{"given":"E. M.","family":"MUNK","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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