{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:52:24Z","timestamp":1772459544505,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T00:00:00Z","timestamp":1177027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u00a0<\/jats:bold> Risk factors for adenocarcinoma of the oesophagus (OAC) and gastric cardia (GCA) are not yet established.<\/jats:p><jats:p><jats:bold>Aim\u00a0<\/jats:bold> To compare environmental risk factors between patients with OAC and GCA.<\/jats:p><jats:p><jats:bold>Methods\u00a0<\/jats:bold> One\u2010hundred and twenty\u2010six patients with OAC, 43 with GCA and 57 with squamous cell carcinoma filled out a questionnaire with information on demographic and lifestyle characteristics, physical activity levels, family history, gastro\u2010oesophageal reflux disease symptoms and medication use.<\/jats:p><jats:p><jats:bold>Results\u00a0<\/jats:bold> OAC and GCA patients were similar with regard to male predominance and age, alcohol intake and smoking, use of fruits and vegetables, body posture and occupational activities (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05). GCA patients less often had heartburn compared with OAC patients [odds ratio (OR) 0.5, 95% confidence interval (CI) 0.2\u20130.96] and had these symptoms less frequently and for a shorter period (OR 0.3, CI 0.1\u20131.0 and OR 0.1, CI 0.03\u20130.6, respectively). Former and current aspirin use was lower among GCA patients than OAC patients (OR 0.2, CI 0.05\u20130.7 and OR 0.4, CI 0.1\u20130.9, respectively), whereas no difference in non\u2010steroidal anti\u2010inflammatory drug use was detected.<\/jats:p><jats:p><jats:bold>Conclusion\u00a0<\/jats:bold> Although OAC and GCA share several environmental risk factors, OAC is more frequently associated with a history of gastro\u2010oesophageal reflux disease, suggesting a more important role for gastro\u2010oesophageal reflux in OAC compared with GCA.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2007.03344.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T11:21:12Z","timestamp":1279884072000},"page":"31-39","source":"Crossref","is-referenced-by-count":22,"title":["Environmental risk factors in the development of adenocarcinoma of the oesophagus or gastric cardia: a cross\u2010sectional study in a Dutch cohort"],"prefix":"10.1111","volume":"26","author":[{"given":"P. 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