{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:07:08Z","timestamp":1780697228500,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T00:00:00Z","timestamp":1177027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold>Nocturnal gastro\u2010oesophageal reflux diseases (GERD) can lead to oesophageal mucosal injury and extra\u2010oesophageal complications.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold>To compare distribution of oesophageal acid exposure during sleep time among patients with non\u2010erosive reflux disease and abnormal pH test (NERD\u2010positive), erosive oesophagitis (EO) and Barrett\u2019s oesophagus (BO).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold>Patients underwent endoscopy followed by 24\u2010h oesophageal pH testing. Oesophageal acid exposure was assessed every 2\u2003h of the sleep period (0\u20132, 2\u20134, 4\u20136 and 6\u20138\u2003h). Each period of 2\u2003h was evaluated for acid reflux parameters. All groups were matched by age, time from last meal and duration of sleep time.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Thirty\u2010eight patients were enrolled (NERD\u2010positive, 16; EO, 1.4; and BO, 8). All GERD groups demonstrated higher oesophageal acid exposure in the first vs. second half of the sleep period as determined by percent time pH &lt;4 (BO: 34.7 vs.11.6, EO: 13.5 vs. 6.9, NERD\u2010positive: 8.8 vs. 2.5, all<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01). In general, patients with BO had a significantly higher distribution of oesophageal acid exposure than those with NERD\u2010positive and EO.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>Oesophageal acid exposure generally declines throughout the sleep period regardless of GERD group, but BO patients demonstrated the greatest decline during the sleep period.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2007.03347.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T11:27:42Z","timestamp":1279884462000},"page":"41-48","source":"Crossref","is-referenced-by-count":43,"title":["Comparisons of the distribution of oesophageal acid exposure throughout the sleep period among the different gastro\u2010oesophageal reflux disease groups"],"prefix":"10.1111","volume":"26","author":[{"given":"R.","family":"DICKMAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"PARTHASARATHY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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