{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:51:50Z","timestamp":1792183910122,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T00:00:00Z","timestamp":1177027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u00a0<\/jats:bold> Beclomethasone dipropionate (BDP) is a second\u2010generation steroid with topical effects and minimal systemic activity for patients with ulcerative colitis (UC).<\/jats:p><jats:p><jats:bold>Aim\u00a0<\/jats:bold> To review all available literature to assess the efficacy of enema\/foam BDP compared with enema\/foam 5\u2010aminosalicylic acid (5\u2010ASA) in the control of left\u2010sided mild\u2013moderate UC.<\/jats:p><jats:p><jats:bold>Methods\u00a0<\/jats:bold> We selected randomized controlled trials of enema\/foam BDP compared with enema\/foam 5\u2010ASA treatment in patients with UC. Two reviewers assessed trial quality and extracted data independently.<\/jats:p><jats:p><jats:bold>Results\u00a0<\/jats:bold> Four trials involving 428 UC patients, 209 treated with 5\u2010ASA (1\u20134\u2003g o.d.) and 219 with BDP (3\u2003mg o.d.), were included. Intention\u2010to\u2010treat analysis showed that 5\u2010ASA induced improvement\/remission of UC in 146 (69.9%) patients, while BDP in 143 (65.3%). The test for heterogeneity (Cochran <jats:italic>Q<\/jats:italic>) was not significant and Mantel\u2013Haenszel pooled estimate of odds ratio was 1.23 (95% CI\u2003=\u20030.82\u20131.85). The results did not change when analysis was performed on a per\u2010protocol basis.<\/jats:p><jats:p><jats:bold>Conclusion\u00a0<\/jats:bold> The randomized controlled trials identified in this review showed that rectal BDP has equal effect as 5\u2010ASA to control symptoms in UC.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2007.03349.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T11:26:44Z","timestamp":1279884404000},"page":"21-29","source":"Crossref","is-referenced-by-count":56,"title":["Meta\u2010analysis: the efficacy of rectal beclomethasone dipropionate vs. 5\u2010aminosalicylic acid in mild to moderate distal ulcerative colitis"],"prefix":"10.1111","volume":"26","author":[{"given":"F.","family":"MANGUSO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"BALZANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4947.1041"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007591624451"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02059.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198428020-00002"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)91747-0"},{"key":"e_1_2_7_7_2","first-page":"1473","article-title":"Topical beclomethasone dipropionate enemas improve distal ulcerative colitis and idiopathic proctitis without systemic toxicity","volume":"88","author":"Levine DS","year":"1985","journal-title":"Gastroenterology"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90621-4"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5104.1072"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5375.89"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000155124.74548.61"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.01.012"},{"key":"e_1_2_7_13_2","first-page":"5","article-title":"Beclometasone dipropionato vs prednisolone sodio fosfato: studio in doppio cieco con clismi nella colite ulcerosa (Risultati preliminari)","volume":"158","author":"Di Blasi M","year":"1999","journal-title":"Gazz Med Ital\u2013Arch Sci Med"},{"key":"e_1_2_7_14_2","first-page":"287","article-title":"Topical treatment of ulcerative colitis. 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