{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:10:14Z","timestamp":1789582214115,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T00:00:00Z","timestamp":1177027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Few studies have compared the efficacy of proton pump inhibitors in resolving the symptoms of non\u2010erosive reflux disease (NERD) and of erosive gastro\u2010oesophageal reflux disease (GERD) in Japan.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To investigate and compare the efficacy of 4\u2010week course of rabeprazole 10\u2003mg\/day on symptom resolution in NERD and erosive GERD in Japan.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> The modified Los Angeles classification was used to grade endoscopically GERD in patients with heartburn (Grades N and M: NERD, Grades A and B: mild reflux oesophagitis (RO), and Grades C and D: severe RO). Rabeprazole 10\u2003mg\/day was administered for 4\u2003weeks to 180 patients who kept symptom diaries.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Complete relief of the symptoms was achieved in 35.8% of the NERD group and 55.4% of the erosive GERD group (mild RO: 51.1% and severe RO: 77.8%). Rabeprazole was significantly more effective in erosive GERD than in NERD patients. Among the NERD subgroups (Grades N and M), no difference in symptom improvement was observed.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Four\u2010week, rabeprazole 10\u2003mg\/day acid suppression therapy was effective in resolving symptoms in Japanese GERD patients. This therapy was more effective in erosive GERD than in NERD patients, and in those with severe RO than in those with mild RO.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2007.03350.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T11:31:44Z","timestamp":1279884704000},"page":"69-77","source":"Crossref","is-referenced-by-count":68,"title":["Efficacy of rabeprazole on heartburn symptom resolution in patients with non\u2010erosive and erosive gastro\u2010oesophageal reflux disease: a multicenter study from Japan"],"prefix":"10.1111","volume":"26","author":[{"given":"H.","family":"MIWA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"SASAKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"FURUTA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"KOIKE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"HABU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"ITO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"FUJIWARA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"WADA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"NAGAHARA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"HONGO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"CHIBA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"KINOSHITA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"THE ACID\u2010RELATED SYMPTOM (ARS) RESEARCH GROUP","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.2008.S1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41217.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(03)00009-1"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02608.x"},{"key":"e_1_2_6_6_2","first-page":"37","article-title":"Natural course of gastroesophageal reflux disease: 17\u201322\u2003year follow\u2010Up of 60 patients","volume":"92","author":"Isolauri J","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-944778"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00829.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01990.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05912.x"},{"key":"e_1_2_6_11_2","first-page":"1459","article-title":"Endoscopic findings of GERD","volume":"62","author":"Hoshihara Y","year":"2004","journal-title":"Nippon Rinsho"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02469.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1775-4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05769.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i20.3091"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03190.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01181.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01207.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510023260"},{"issue":"1","key":"e_1_2_6_20_2","first-page":"7","article-title":"Non\u2010erosive reflux disease and atypical gastro\u2010oesophageal reflux disease manifestations: treatment results","volume":"66","author":"Galmiche JP","year":"2006","journal-title":"Drugs"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.00198.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709011211"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.17.s2.14.x"}],"container-title":["Alimentary Pharmacology &amp; 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