{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:37:11Z","timestamp":1788305831055,"version":"build-2803163510"},"reference-count":75,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,4,22]],"date-time":"2007-04-22T00:00:00Z","timestamp":1177200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold>Sodium\u2010phosphate enemas are widely used to treat constipation, and are rarely associated with side effects.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold>A systematic review of the literature was conducted to identify the most common adverse effects of sodium\u2010phosphate enemas and associated risk factors.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold>A systematic search was conducted in Internet (MEDLINE), and the Cochrane Library, from January 1957 to March 2007.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>A total of 761 references were identified initially, and 39 relevant papers were finally selected. The most common therapeutic indications included constipation (63%). Sixty\u2010eight per cent of the patients having adverse effects had associated conditions, the most common being gastrointestinal motility disorders, cardiological diseases and renal failure. Virtually, all side effects were due to water and electrolyte disturbances. Most patients were under 18\u2003years of age (66%) or older than 65\u2003years (25%). A total of 12 deaths were found.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold>The main side effects caused by sodium phosphate enemas are water and electrolyte disturbances. The main risk factors are extreme age and associated comorbidity.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2007.03354.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T11:51:36Z","timestamp":1279885896000},"page":"9-20","source":"Crossref","is-referenced-by-count":104,"title":["Systematic review: the adverse effects of sodium phosphate enema"],"prefix":"10.1111","volume":"26","author":[{"given":"J.","family":"MENDOZA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"LEGIDO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"RUBIO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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