{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:41:53Z","timestamp":1780062113281,"version":"3.54.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,5,4]],"date-time":"2007-05-04T00:00:00Z","timestamp":1178236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u00a0<\/jats:bold> The <jats:sup>13<\/jats:sup>C\u2010methacetin breath test (MBT) has been proposed for the non\u2010invasive evaluation of hepatic microsomal activity.<\/jats:p><jats:p><jats:bold>Aim\u00a0<\/jats:bold> To test a new continuous breath analysis system (BreathID) in comparison with gold\u2010standard isotopic ratio mass spectrometry (IRMS) in patients with chronic hepatitis C infection and to assess the diagnostic performance of these validation data compared with liver biopsy for the quantification of liver fibrosis.<\/jats:p><jats:p><jats:bold>Methods\u00a0<\/jats:bold> Fifty patients at different METAVIR stages received 75\u2003mg of <jats:sup>13<\/jats:sup>C\u2010methacetin. Breath isotopic ratio was analysed over 90\u2003min by BreathID (one sample\/3\u2003min; BreathID) and IRMS (one sample\/10\u2003min). Results were expressed as delta over baseline [DOB (%)] at each time interval and maximal DOB [DOB<jats:sub>max<\/jats:sub>(%)].<\/jats:p><jats:p><jats:bold>Results\u00a0<\/jats:bold> A high linear association between both methods was observed (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2003=\u20030.95, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). For all DOB and DOB<jats:sub>max<\/jats:sub>, the limits of agreement by Bland\u2013Altman analysis were within the predefined maximal width of s.d. &lt;2.5%. MBT parameters in patients with high\u2010grade fibrosis were different from patients with low\u2010grade fibrosis (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001).<\/jats:p><jats:p><jats:bold>Conclusion\u00a0<\/jats:bold> The MBT obtained by an easy to operate, automated BreathID provides results comparable with standard IRMS and differentiates fibrosis grades in patients with chronic hepatitis C infection.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2007.03360.x","type":"journal-article","created":{"date-parts":[[2009,11,20]],"date-time":"2009-11-20T04:02:02Z","timestamp":1258689722000},"page":"305-311","source":"Crossref","is-referenced-by-count":35,"title":["<sup>13<\/sup>C\u2010methacetin breath test as a quantitative liver function test in patients with chronic hepatitis C infection: continuous automatic molecular correlation spectroscopy compared to isotopic ratio mass spectrometry"],"prefix":"10.1111","volume":"26","author":[{"given":"O.","family":"GOETZE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"SELZNER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"FRUEHAUF","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"FRIED","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"GERLACH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"MULLHAUPT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000179465.48571.d5"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260609"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01059282"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi0491393"},{"key":"e_1_2_6_6_2","first-page":"33","article-title":"13C\u2010breath tests in the study of microsomal liver function","volume":"8","author":"Nista EC","year":"2004","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160311"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840210121"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296285"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i1.142"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01824.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90704-1"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240201"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1010103"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/33.11.2375"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609006762"},{"key":"e_1_2_6_17_2","first-page":"235","article-title":"Substrate utilization during prolonged exercise after ingestion of 13C\u2010glucose in obese and control subjects","volume":"4","author":"Ravussin E","year":"1980","journal-title":"Int J Obes"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80601-5"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_6_20_2","first-page":"1645","article-title":"New nondispersive infrared spectrometry in 13C\u2010urea breath tests","volume":"128","author":"Hartmann D","year":"2003","journal-title":"Dtsch Med Wochenschr"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01067.x"},{"key":"e_1_2_6_22_2","unstructured":"R development Core Team.R a language and environment for statistical computing reference index version 2.0.1.R Foundation for Statistical Computing Vienna Austria 2004."},{"issue":"5","key":"e_1_2_6_23_2","first-page":"S3","article-title":"Management of hepatitis C: 2002\u2010June 10\u201312, 2002","volume":"36","author":"National Institutes of Health Consensus Development Conference Statement","year":"2002","journal-title":"Hepatology"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01290.x"},{"key":"e_1_2_6_25_2","first-page":"1139","article-title":"13C\u2010methacetin breath test: isotope\u2010selective nondispersive infrared spectrometry in comparison to isotope ratio mass spectrometry in volunteers and patients with liver cirrhosis","volume":"37","author":"Adamek RJ","year":"1999","journal-title":"Z Gastroenterol"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02317.x"}],"container-title":["Alimentary Pharmacology &amp; 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