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HRQoL and digestive symptoms were assessed after 3 and 6\u2003weeks on an intention\u2010to\u2010treat population of 267 subjects.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The HRQoL discomfort score, the primary endpoint, improved (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) in both groups at weeks 3 and 6. The responder rate for the HRQoL discomfort score was higher (65.2 vs. 47.7%, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.005), as was the decrease in bloating score [0.56\u2003\u00b1\u2003(s.d.)1.01 vs. 0.31\u2003\u00b1\u20030.87, <jats:italic>P<\/jats:italic>\u2003=\u20030.03], at week 3 in the test vs. the control group. In those subjects with &lt;3 stools\/week, stool frequency increased (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) over 6\u2003weeks in the test vs. control group.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> This study suggests a beneficial effect of a probiotic food on discomfort HRQoL score and bloating in constipation\u2010predominant IBS, and on stool frequency in subjects with &lt;3 stools\/week.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2007.03362.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T11:54:28Z","timestamp":1279886068000},"page":"475-486","source":"Crossref","is-referenced-by-count":301,"title":["Effect of a fermented milk containing <i>Bifidobacterium animalis<\/i> DN\u2010173 010 on the health\u2010related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double\u2010blind, controlled trial"],"prefix":"10.1111","volume":"26","author":[{"given":"D.","family":"GUYONNET","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"CHASSANY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"DUCROTTE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"PICARD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"MOURET","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010H.","family":"MERCIER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"MATUCHANSKY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37095"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0399-8320(04)95011-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02038.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i17.2708"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02938.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2005.05.008"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2008.ii43"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.06.062"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0399-8320(06)73160-8"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200605000-00004"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.16484"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.t01-1-01736.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02015.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00695.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.050"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00734.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2005.06.001"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200603000-00020"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000156104.67505.5b"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-006-0053-1"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/089106001753341291"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/08910600310015565"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01188.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.12938\/bifidus1996.20.43"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(91)78183-6"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/55.1.78"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.2000.01073.x"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.4.527"},{"key":"e_1_2_6_31_2","volume-title":"Patient\u2010reported outcome measures:\u2003use in medical product development to support labelling claims","author":"FDA Guidance for Industry","year":"2006"},{"key":"e_1_2_6_32_2","volume-title":"Committee for proprietary medicinal products (CPMP). 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