{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T01:51:55Z","timestamp":1777081915297,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,5,11]],"date-time":"2007-05-11T00:00:00Z","timestamp":1178841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Aim<\/jats:bold> To provide estimates of actual costs to deliver health care to patients with functional bowel disorders, and to assess the cost impact of symptom severity, recency of onset, and satisfaction with treatment.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> We enrolled 558 irritable bowel (IBS), 203 constipation, 243 diarrhoea and 348 abdominal pain patients from primary care and gastroenterology clinics at a health maintenance organization within weeks of a visit. Costs were extracted from administrative claims. Symptom severity, satisfaction with treatment and out\u2010of\u2010pocket expenses were assessed by questionnaires.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> Average age was 52\u2003years, 27% were males, and 59% participated. Eighty percent were seen in primary care clinics. Mean annual direct health care costs were $5049 for IBS, $6140 for diarrhoea, $7522 for constipation and $7646 for abdominal pain. Annual out\u2010of\u2010pocket expenses averaged $406 for treatment of IBS symptoms, $294 for diarrhoea, $390 for constipation and $304 for abdominal pain. Lower gastrointestinal costs comprised 9% of total costs for IBS, 9% for diarrhoea, 6.5% for constipation and 9% for abdominal pain. In\u2010patient care accounted for 17.5% of total costs (15.2% IBS).<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> Costs were affected by disease severity (increased), recent exacerbation of bowel symptoms (increased), and whether the patient was consulting for the first time (decreased).<\/jats:p>","DOI":"10.1111\/j.1365-2036.2007.03370.x","type":"journal-article","created":{"date-parts":[[2009,11,20]],"date-time":"2009-11-20T04:02:02Z","timestamp":1258689722000},"page":"237-248","source":"Crossref","is-referenced-by-count":157,"title":["Costs of health care for irritable bowel syndrome, chronic constipation, functional diarrhoea and functional abdominal pain"],"prefix":"10.1111","volume":"26","author":[{"given":"K. A.","family":"NYROP","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. S.","family":"PALSSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. L.","family":"LEVY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. VON","family":"KORFF","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. D.","family":"FELD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"TURNER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. E.","family":"WHITEHEAD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,11]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05913.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.025"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200624010-00002"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02256.x"},{"key":"e_1_2_7_6_2","first-page":"247","volume-title":"Pharmacoepidemiology","author":"Saunders KW","year":"1994"},{"key":"e_1_2_7_7_2","first-page":"669","volume-title":"Diagnosis, Pathophysiology and Treatment: A Multinational Consensus","author":"Drossman DA","year":"2000"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.142318000.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01941.x"},{"key":"e_1_2_7_10_2","volume-title":"Brief Symptom Inventory (BSI) administration, scoring, and procedures manual (3rd edn.)","author":"Derogatis LR","year":"1993"},{"key":"e_1_2_7_11_2","first-page":"577","volume-title":"Rome II: The Functional Gastrointestinal Disorders","author":"VanZanten SJOV","year":"2000"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01766.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.05258.x"},{"key":"e_1_2_7_14_2","volume-title":"The burden of gastrointestinal diseases","author":"American Gastroenterological Association","year":"2001"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)91023-Y"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32978"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2007.03370.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2007.03370.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T23:31:47Z","timestamp":1697239907000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2007.03370.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,11]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["10.1111\/j.1365-2036.2007.03370.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2007.03370.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,11]]}}}