{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:38:57Z","timestamp":1765039137852},"reference-count":71,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T00:00:00Z","timestamp":1180051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Aspirin chemoprevention combined with colonoscopy screening is not cost\u2010effective for the general population. However, the cost\u2010effectiveness of aspirin in individuals with prior adenoma resection has not been evaluated.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To evaluate the cost\u2010effectiveness of aspirin chemoprevention alone and in combination with colonoscopy surveillance in patients with prior adenoma resection.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A model of the natural history of individuals with a history of endoscopic polypectomy was constructed. Four strategies were compared: (i) no intervention, (ii) routine colonoscopy surveillance, (iii) aspirin chemoprevention alone, and (iv) aspirin therapy combined with colonoscopy.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Compared with no intervention, all other strategies were more costly but were associated with gains in years of life saved. Aspirin chemoprevention alone was associated with a gain of 0.0092\u2003years, whereas routine colonoscopic surveillance and combination strategy were associated with further gains in years of life saved (0.0124 and 0.0138\u2003years, respectively). Compared with no intervention, the incremental cost\u2010effectiveness ratio of routine colonoscopy surveillance was $78\u2003226 per year of life saved, and the incremental cost\u2010effectiveness ratio of combination aspirin and colonoscopy was $60\u2003942 per year of life saved.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Aspirin chemoprevention combined with colonoscopic surveillance in post\u2010polypectomy patients may be considered a cost\u2010effective strategy.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2007.03380.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T12:28:08Z","timestamp":1279888088000},"page":"431-441","source":"Crossref","is-referenced-by-count":18,"title":["Aspirin chemoprevention in patients with increased risk for colorectal cancer: a cost\u2010effectiveness analysis"],"prefix":"10.1111","volume":"26","author":[{"given":"A. 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