{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T13:55:40Z","timestamp":1794491740860,"version":"4.9.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T00:00:00Z","timestamp":1180051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> Proton pump inhibitors (PPI) therapy \u2018on\u2010demand\u2019 is often used as an alternative to continuous maintenance therapy in gastro\u2010oesophageal reflux disease (GERD).<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> We conducted a systematic review with the specific objectives to ascertain whether on\u2010demand PPI therapy was effective in preventing symptomatic relapse and to assess the relative efficacy of on\u2010demand vs. continuous PPI maintenance strategy.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> Randomized\u2010controlled clinical trials comparing on\u2010demand PPI vs. placebo or on\u2010demand vs. continuous PPI therapy in GERD patients were identified by searching the Medline database and the Cochrane Controlled Trials Register.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> Seventeen studies were found which met inclusion criteria. Out of the 17 studies: five investigated exclusively patients with non\u2010erosive reflux disease (NERD), four patients with NERD and mild oesophagitis, two patients with erosive oesophagitis only, and two patients with uninvestigated GERD symptoms, respectively. Four further studies were not investigating the effectiveness of the therapies but primarily pharmacoeconomic or quality of life parameters.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> On the basis of the analysis of 17 studies, we can conclude that on\u2010demand therapy with currently available PPI appears to be effective in the long\u2010term management of patients with NERD or mild and uninvestigated forms of GERD, but not in patients with (severe) erosive oesophagitis.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2007.03381.x","type":"journal-article","created":{"date-parts":[[2009,11,20]],"date-time":"2009-11-20T04:02:02Z","timestamp":1258689722000},"page":"195-204","source":"Crossref","is-referenced-by-count":83,"title":["Systematic review: maintenance treatment of gastro\u2010oesophageal reflux disease with proton pump inhibitors taken \u2018on\u2010demand\u2019"],"prefix":"10.1111","volume":"26","author":[{"given":"F.","family":"PACE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"TONINI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"PALLOTTA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"MOLTENI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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