{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:19:56Z","timestamp":1789521596391,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,5,24]],"date-time":"2007-05-24T00:00:00Z","timestamp":1179964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> At present, the efficacy of proton pump inhibitor\u2010clarithromycin\u2010amoxicillin regimen is relatively low.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> To evaluate the efficacy and tolerability of a first\u2010line triple clarithromycin\u2010free regimen including ranitidine bismuth citrate, levofloxacin and amoxicillin.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold>  <jats:italic>Design<\/jats:italic>: Prospective study. <jats:italic>Patients<\/jats:italic>: <jats:italic>Helicobacter pylori<\/jats:italic>\u2010positive patients complaining of dyspeptic symptoms referred for gastroscopy. <jats:italic>Intervention<\/jats:italic>: Levofloxacin (500\u2003mg b.d.), amoxicillin (1\u2003g b.d.) and ranitidine bismuth citrate (400\u2003mg b.d.) was prescribed for 10\u2003days. <jats:italic>Outcome<\/jats:italic>: Eradication was confirmed by a <jats:sup>13<\/jats:sup>C\u2010urea breath test 8\u2003weeks after therapy. Compliance with therapy was determined by questioning and the recovery of empty envelopes of medications. Incidence of adverse effects was evaluated by means of a specific questionnaire.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> Sixty\u2010four patients were included (30% peptic ulcer, 70% functional dyspepsia). Almost all (97%) patients took all the medications correctly. Per\u2010protocol and intention\u2010to\u2010treat eradication rates were 88.5% (95% CI\u2003=78\u201395%) and 84.4 (74\u201391%). Adverse effects were reported in 9.5% of the patients, mainly including diarrhoea (7.9%); none of them were severe.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> This new 10\u2010day levofloxacin\u2010based combination represents an alternative to clarithromycin\u2010based therapy, as it meets the criteria set for regimens used as primary <jats:italic>H. pylori<\/jats:italic> treatment: effectiveness (&gt;80%), simplicity (twice\u2010daily dosing and excellent compliance) and safety (low incidence of adverse effects).<\/jats:p>","DOI":"10.1111\/j.1365-2036.2007.03384.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T12:16:06Z","timestamp":1279887366000},"page":"495-500","source":"Crossref","is-referenced-by-count":38,"title":["First\u2010line triple therapy with levofloxacin for <i>Helicobacter pylori<\/i> eradication"],"prefix":"10.1111","volume":"26","author":[{"given":"J. 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