{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:49:13Z","timestamp":1761630553584},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,7,7]],"date-time":"2007-07-07T00:00:00Z","timestamp":1183766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Epidemiological data on chronic atrophic gastritis from general population samples are sparse in Germany.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess prevalence of chronic atrophic gastritis according to potential risk factors and clinical outcomes in a large\u2010scale population\u2010based study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the baseline examination of ESTHER, a population\u2010based cohort study conducted in Germany, serological measurements of pepsinogen (PG) I and II and <jats:italic>Helicobacter pylori<\/jats:italic> antibodies were taken in 9444 women and men aged 50\u201374\u2003years. Information on potential risk factors and medical history were obtained by questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With the definition used in the EUROGAST study (PG I\u2003&lt;\u200325\u2003ng\/mL), prevalence of chronic atrophic gastritis increased from 4.8% in age group 50\u201354 to 8.7% in age group 70\u201374. An alternative definition of chronic atrophic gastritis (PG I\u2003&lt;\u200370\u2003ng\/mL and PG I\/PG II\u2003&lt;\u20033), used in multiple studies from Japan, revealed a greater increase with age (from 2.7% to 9.1%) and a strong association with <jats:italic>H. pylori<\/jats:italic> infection (adjusted odds ratio: 2.9, 95% confidence interval: 2.4\u20133.7). With both definitions, a strong inverse association with heartburn was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall chronic atrophic gastritis prevalence is low among older adults in Germany, but it strongly increases with age and <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2007.03430.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T12:23:32Z","timestamp":1279887812000},"page":"879-887","source":"Crossref","is-referenced-by-count":62,"title":["Epidemiology of chronic atrophic gastritis: population\u2010based study among 9444 older adults from Germany"],"prefix":"10.1111","volume":"26","author":[{"given":"M. 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