{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T23:39:50Z","timestamp":1787269190309,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,7,12]],"date-time":"2007-07-12T00:00:00Z","timestamp":1184198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> Primary biliary cirrhosis (PBC) may be associated with various rheumatological disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the frequency and significance of \u2018rheumatological\u2019 antinuclear antibodies in the field of autoimmune chronic liver disease, with special regard to PBC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 105 patients with PBC, 162 autoimmune liver disease controls (type 1 and 2 autoimmune hepatitis, primary sclerosing cholangitis), 30 systemic lupus erythematosus and 50 blood donors. Sera were tested for the presence of antibodies to extractable nuclear antigens (anti\u2010ENA) by counterimmunoelectrophoresis, enzyme\u2010linked and immunoblot (IB) assay, and for the presence of anti\u2010centromere antibodies (ACA) by indirect immunofluorescence on HEp\u20102 cells and IB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall prevalence of IB\u2010detected anti\u2010ENA in PBC (30%) was higher than in type 1 autoimmune hepatitis (2.5%, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001), type 2 autoimmune hepatitis (0%, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001) and primary sclerosing cholangitis (11.5%, <jats:italic>P<\/jats:italic>\u2003=\u20030.006) and lower than in systemic lupus erythematosus (53%, <jats:italic>P<\/jats:italic>\u2003=\u20030.03). The most frequent anti\u2010ENA reactivity in PBC was anti\u2010SSA\/Ro\u201052kD (28%). ACA were detected by IB in 21% PBC patients and never in the other subjects (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). Anti\u2010SS\u2010A\/Ro\/52kD positive PBC patients had at the time of diagnosis a more advanced histological stage (<jats:italic>P<\/jats:italic>\u2003=\u20030.01) and higher serum levels of bilirubin (<jats:italic>P<\/jats:italic>\u2003=\u20030.01) and IgM (<jats:italic>P<\/jats:italic>\u2003=\u20030.03) compared with negative ones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the autoimmune liver disease setting, anti\u2010SS\u2010A\/Ro\u201052kD and ACA have a high specificity for PBC and can thus be of diagnostic relevance in anti\u2010mitochondrial antibodies negative cases. If confirmed in further studies with adequate follow\u2010up, anti\u2010SS\u2010A\/Ro\u201052kD antibodies might identify PBC patients with a more advanced and active disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2007.03433.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T12:35:05Z","timestamp":1279888505000},"page":"831-838","source":"Crossref","is-referenced-by-count":81,"title":["Antibodies to SS\u2010A\/Ro\u201052kD and centromere in autoimmune liver disease: a clue to diagnosis and prognosis of primary biliary cirrhosis"],"prefix":"10.1111","volume":"26","author":[{"given":"A.","family":"GRANITO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"MURATORI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"MURATORI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"PAPPAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"CASSANI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"WORTHINGTON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"FERRI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"QUARNETI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"CIPRIANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"DE MOLO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"LENZI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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B.","family":"BIANCHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,12]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13808-1"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20907"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2006.06.002"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-916321"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6942(03)00029-9"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.11.1046"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.11.2.297-301.2004"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1313.035"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5984"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043898"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80297-9"},{"key":"e_1_2_8_14_2","first-page":"1","article-title":"Primary sclerosing cholangitis","volume":"24","author":"Worthington J","year":"2006","journal-title":"Orphanet J Rare Dis"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199909)42:9<1785::AID-ANR1>3.0.CO;2-#"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.41.5.554"},{"key":"e_1_2_8_17_2","first-page":"588","article-title":"Precipitating antibodies to rabbit thymus extractable antigens in chronic liver disease: relationship with anti\u2010actin antibodies","volume":"68","author":"Cassani F","year":"1987","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.38.7.801"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90078-7"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018880429469"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240616"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1995.tb01597.x"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409092488"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.2.148"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.075002"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00465-3"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2007.03433.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2007.03433.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:50:33Z","timestamp":1697233833000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2007.03433.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,12]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1111\/j.1365-2036.2007.03433.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2007.03433.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,12]]}}}