{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:11:42Z","timestamp":1767651102059},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,7,28]],"date-time":"2007-07-28T00:00:00Z","timestamp":1185580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The use of non\u2010steroidal anti\u2010inflammatory drugs (NSAID) is associated with an increased risk of gastric ulcer (GU) development.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> This multicentre, randomized, double\u2010blind, parallel\u2010group trial compared endoscopic healing rates at 4 and 8\u2003weeks after treatment with oral esomeprazole 40 or 20\u2003mg once daily, or ranitidine 150\u2003mg twice daily, in patients with 1 baseline GU\u2003\u22655\u2003mm but no GUs or duodenal ulcers &gt;25\u2003mm in diameter who received continued cyclooxygenase\u20102\u2013selective or non\u2010selective NSAID therapies. The primary outcome was the percentage of patients in each treatment group who had no GUs at week 8.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Four hundred and forty patients were randomized to treatment. At week 8, GU healing rates (95% CI) with esomeprazole 40\u2003mg, esomeprazole 20\u2003mg and ranitidine were 85.7 (79.8\u201391.7)%, 84.8 (78.8\u201390.8)% and 76.3 (69.2\u201383.3)%, respectively; between\u2010group differences were not statistically significant. Week\u20104 GU healing rates were 70.7 (62.9\u201378.4)% and 72.5 (65.0\u201379.9)% with esomeprazole 40 and 20\u2003mg, respectively, and were significantly higher (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.01 for both doses) than those with ranitidine [55.4 (47.1\u201363.7)%].<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> In patients who require continued NSAID therapy, GU healing rates at 8\u2003weeks numerically favoured esomeprazole but were not significantly different from ranitidine.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2007.03460.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T11:35:04Z","timestamp":1279884904000},"page":"1101-1111","source":"Crossref","is-referenced-by-count":41,"title":["Clinical trial: healing of NSAID\u2010associated gastric ulcers in patients continuing NSAID therapy \u2013 a randomized study comparing ranitidine with esomeprazole"],"prefix":"10.1111","volume":"26","author":[{"given":"J. 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