{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T00:30:22Z","timestamp":1697329822766},"reference-count":11,"publisher":"Wiley","issue":"s2","license":[{"start":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T00:00:00Z","timestamp":1196985600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Therapeutic success in the treatment of gastro\u2010oesophageal reflux disease cannot be measured by endoscopic healing or symptomatic relief alone. Assessment of treatment efficacy should be based on symptomatic relief <jats:italic>and<\/jats:italic> endoscopic healing. As most questionnaires focus on heartburn, it is important to stress that there is more to gastro\u2010oesophageal reflux disease than just heartburn. The \u2018complete remission\u2019 concept was recently introduced; an approach in which endoscopic appearances and symptomatic relief are integrated, thus allowing the full gastro\u2010oesophageal reflux disease picture and its changes over time to be described in a simple and accurate manner. Complete remission is defined as the absence of both oesophagitis and symptoms. ReQuest, a relatively new questionnaire acceptable as a clinical endpoint in trials, seems to be of use in daily practice.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To review the utility of the ReQuest questionnaire.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> This questionnaire assesses the gastro\u2010oesophageal reflux disease symptom profile using 67 symptom descriptions adapted from patients\u2019 view, doctors\u2019 view, clinical trials and from the literature. Individual symptoms are reduced to seven dimensions by factor analysis and expert consensus. This gives insight into multiple symptoms over time as well as individual patient profiles. ReQuest determines symptom relief using a gastro\u2010oesophageal reflux disease symptom threshold. This unique concept allows the doctor to measure the time to <jats:italic>first<\/jats:italic> symptom relief and also to <jats:italic>sustained<\/jats:italic> symptom relief.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> ReQuest makes it possible to evaluate the complete symptom spectrum in patients with non\u2010erosive oesophageal reflux disease and gastro\u2010oesophageal reflux disease. ReQuest is available for daily practice to use for comparability with regard to treatment efficacy.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2007.03493.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T13:57:47Z","timestamp":1279893467000},"page":"13-16","source":"Crossref","is-referenced-by-count":4,"title":["Review article: gastro\u2010oesophageal reflux disease \u2013 application of the concept of complete remission"],"prefix":"10.1111","volume":"26","author":[{"given":"M.","family":"OUDKERK POOL","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,7]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70025-8"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02043.x"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000079707"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07531.x"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(03)02011-X"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-5157(03)00046-1"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2004.01861.x"},{"key":"e_1_2_3_10_2","first-page":"9","article-title":"The complete remission concept","volume":"42","author":"M\u00f6nnikes H","year":"2006","journal-title":"Drugs Today"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000085564"},{"key":"e_1_2_3_12_2","first-page":"A62","article-title":"Application of the complete remission concept: many patients with GERD are incompletely treated by a standard proton pump inhibitor (PPI) regime","volume":"55","author":"Heading RC","year":"2006","journal-title":"Gut"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2007.03493.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2007.03493.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T15:03:39Z","timestamp":1695740619000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2007.03493.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":11,"journal-issue":{"issue":"s2","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1111\/j.1365-2036.2007.03493.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2007.03493.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}