{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:48:17Z","timestamp":1790664497634,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,1,31]],"date-time":"2008-01-31T00:00:00Z","timestamp":1201737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Irritable bowel syndrome is the most common disorder diagnosed by gastroenterologists. Although several randomized\u2010controlled trials have assessed the therapeutic role of antidepressant drugs, there is insufficient evidence to support their use.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To compare the effects of low\u2010dose amitriptyline in the treatment of diarrhoea\u2010predominant irritable bowel syndrome in a double\u2010blind randomized\u2010controlled trial.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Fifty\u2010four patients who fulfilled Rome II criteria for diarrhoea\u2010predominant irritable bowel syndrome were included in this study. Organic causes were ruled out by standard laboratory and radiological tests, and rectosigmoidoscopy. Patients were randomly assigned to receive either 10\u2003mg amitriptyline daily or placebo. Subjects were followed up for 2\u2003months and symptoms were assessed using a questionnaire. Intention\u2010to\u2010treat and per\u2010protocol analysis was performed.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Fifty patients completed the study. At 2\u2003months, the amitriptyline group showed greater (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) reduction in the incidence of loose stool and feeling of incomplete defecation. Patients receiving amitriptyline showed greater complete response, defined as loss of all symptoms, compared with those receiving placebo (68% vs. 28%, <jats:italic>P<\/jats:italic>\u2003=\u20030.01). Adverse effects were similar between the two groups.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Amitriptyline may be effective in the treatment of diarrhoea\u2010predominant irritable bowel syndrome and at low dose is well tolerated.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2008.03633.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T14:18:20Z","timestamp":1279894700000},"page":"678-684","source":"Crossref","is-referenced-by-count":120,"title":["Clinical trial: the effect of amitriptyline in patients with diarrhoea\u2010predominant irritable bowel syndrome"],"prefix":"10.1111","volume":"27","author":[{"given":"H.","family":"VAHEDI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"MERAT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"MOMTAHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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