{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:50:30Z","timestamp":1772585430284,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T00:00:00Z","timestamp":1278633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:sec><jats:label\/><jats:p> <jats:italic>Aliment Pharmacol Ther<\/jats:italic> 2010; <jats:bold>32:<\/jats:bold> 664\u2013669<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Treatment with fluoroquinolones is associated with the development of <jats:italic>Clostridium difficile<\/jats:italic> and extended spectrum beta\u2010lactamase\u2010producing bacteria (ESBL). <jats:italic>Clostridium difficile<\/jats:italic> and ESBL are resistant to many antibiotics and each may cause pouchitis after restorative proctocolectomy (RPC) refractory to empirical antibiotic therapy.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To assess the prevalence and establish risk factors for the development of ESBL and <jats:italic>Clostridium difficile<\/jats:italic> toxins (CDT) in RPC patients with recurrent or refractory pouchitis under follow\u2010up at our institution over a 1\u2010year period.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> An enzyme\u2010linked immunosorbent assay was used to detect CDT and a culture technique was used to identity ESBL in faecal samples. All patients had previously received fluoroquinolone treatment.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Forty\u2010eight patients (35 (74%) men; median age 42\u2003years) underwent testing at a median interval from RPC of 8 (range 1\u201325)\u2003years. No patient had a positive CDT result, but ESBL bacteria were identified in 16 (33%) samples. ESBL positivity was significantly related to prepouch ileitis (<jats:italic>P<\/jats:italic>\u2003=\u20030.035) and maintenance antibiotic therapy (<jats:italic>P<\/jats:italic>\u2003=\u20030.039).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Extended spectrum beta\u2010lactamase, but not CDT, is a common finding in faecal samples from patients with recurrent or refractory pouchitis. Treatment with maintenance antibiotics and prepouch ileitis are risk factors for developing ESBL\u2010producing bacteria.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2010.04401.x","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T04:09:47Z","timestamp":1278648587000},"page":"664-669","source":"Crossref","is-referenced-by-count":13,"title":["Extended spectrum beta\u2010lactamase\u2010producing bacteria and <i>Clostridium difficile<\/i> in patients with pouchitis"],"prefix":"10.1111","volume":"32","author":[{"given":"S. D.","family":"McLaughlin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z. L.","family":"Perry\u2010Woodford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. P.","family":"Tekkis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Ciclitira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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