{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:34:41Z","timestamp":1778682881138,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,8,15]],"date-time":"2010-08-15T00:00:00Z","timestamp":1281830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec><jats:label\/><jats:p> <jats:italic>Aliment Pharmacol Ther<\/jats:italic> 2010; <jats:bold>32:<\/jats:bold> 884\u2013893<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The short\u2010term effects of methylnaltrexone (MNTX), a peripherally acting \u03bc\u2010opioid receptor antagonist, on gastrointestinal and colonic transit remain unclear.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To compare the effects of placebo, codeine, subcutaneous (s.c.) MNTX and codeine with s.c. MNTX on gastrointestinal and colonic transit of solids in healthy humans.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In a randomized, parallel\u2010group, double\u2010blind, placebo\u2010controlled trial of 48 healthy volunteers, effects of 6 consecutive days of placebo [s.c. and p.o. (orally), <jats:italic>n<\/jats:italic>\u2003=\u20038], codeine (p.o. 30\u2003mg q.d.s., <jats:italic>n<\/jats:italic>\u2003=\u20038), MNTX (s.c. 0.30\u2003mg\/kg, <jats:italic>n<\/jats:italic>\u2003=\u200316) and combined MNTX and codeine (same doses and routes, <jats:italic>n<\/jats:italic>\u2003=\u200316) on gastrointestinal and colonic transit were assessed. A validated scintigraphic method was used to measure transit during the last 48\u2003h of treatment. Bowel function was estimated during treatment as well as 1\u2003week preceding treatment using standard diaries. Analysis of covariance was used to assess treatment effects.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Codeine delayed colonic transit [geometric centre at 24\u2003h (<jats:italic>P<\/jats:italic>\u2003=\u20030.04) and ascending colon <jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub> (<jats:italic>P<\/jats:italic>\u2003=\u20030.02)] and reduced stool frequency (<jats:italic>P<\/jats:italic>\u2003=\u20030.002), but had no effect on stool form. MNTX did not affect transit, stool frequency or stool form, either alone or with codeine (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.3). No drug interaction effects were detected (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.15).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Methylnaltrexone does not alter gastrointestinal or colonic transit and does not reverse acute codeine\u2010associated delayed gut transit in health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2010.04422.x","type":"journal-article","created":{"date-parts":[[2010,8,16]],"date-time":"2010-08-16T00:22:27Z","timestamp":1281918147000},"page":"884-893","source":"Crossref","is-referenced-by-count":34,"title":["The effects of methylnaltrexone alone and in combination with acutely administered codeine on gastrointestinal and colonic transit in health"],"prefix":"10.1111","volume":"32","author":[{"given":"B. S.","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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