{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:45:38Z","timestamp":1757706338778},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,8,15]],"date-time":"2010-08-15T00:00:00Z","timestamp":1281830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec><jats:label \/><jats:p> <jats:italic>Aliment Pharmacol Ther<\/jats:italic> 2010; <jats:bold>32:<\/jats:bold> 1023\u20131030<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Acid reflux is often difficult to control medically.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To assess the effect of 40\u2003mg twice daily esomeprazole (high\u2010dose) on gastric and oesophageal pH and symptoms, and biomarkers relevant to adenocarcinoma, in patients with Barrett\u2019s oesophagus (BO).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Eighteen patients, treated with proton pump inhibitors as prescribed by their treating doctor, had their therapy increased to high\u2010dose esomeprazole for 6\u2003months.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> At entry into the study, 9\/18 patients had excessive 24\u2010h oesophageal acid exposure, and gastric pH remained &lt;4 for &gt;16\u2003h in 8\/18. With high\u2010dose esomeprazole, excessive acid exposure occurred in 2\/18 patients, and gastric pH &lt;4 was decreased from 38% of overall recording time and 53% of the nocturnal period to 15% and 17%, respectively (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). There was a reduction in self\u2010assessed symptoms of heartburn (<jats:italic>P<\/jats:italic>\u2003=\u20030.0005) and regurgitation (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001), and inflammation and proliferation in the Barrett\u2019s mucosa. There was no significant change in p53, MGMT or COX\u20102 expression, or in aberrant DNA methylation.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> High\u2010dose esomeprazole achieved higher levels of gastric acid suppression and control of oesophageal acid reflux and symptoms, with significant decreases in inflammation and epithelial proliferation. There was no reversal of aberrant DNA methylation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2010.04428.x","type":"journal-article","created":{"date-parts":[[2010,8,16]],"date-time":"2010-08-16T00:28:53Z","timestamp":1281918533000},"page":"1023-1030","source":"Crossref","is-referenced-by-count":18,"title":["The effects of high\u2010dose esomeprazole on gastric and oesophageal acid exposure and molecular markers in Barrett\u2019s oesophagus"],"prefix":"10.1111","volume":"32","author":[{"given":"A.","family":"Abu\u2010Sneineh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Tam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Schoeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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