{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:29:41Z","timestamp":1785767381819,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,9,29]],"date-time":"2010-09-29T00:00:00Z","timestamp":1285718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec><jats:label\/><jats:p> <jats:italic>Aliment Pharmacol Ther<\/jats:italic> 2010; <jats:bold>32:<\/jats:bold> 1266\u20131274<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Factors associated with non\u2010erosive reflux disease (NERD) and erosive oesophagitis (EO) are incompletely understood and the overlap between the two entities is debated.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To compare clinical, demographic, and endoscopic findings in a large cohort of NERD and EO patients.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> After they completed a validated GERD questionnaire, patients who presented for index endoscopy were enrolled and categorized as NERD or EO. Analysis was performed using Chi\u2010square, Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test and multivariate logistic regression.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A total of 696 GERD patients [455 (65.4%) NERD; 241 (34.6%) EO]; mean age 57\u2003years; 92% men and 82% Caucasian were prospectively enrolled. Using logistic regression, patients on PPI were more likely to be classified as NERD (OR: 3.2; <jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001). NERD patients were older (OR: 1.50; <jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.05), less likely to have nocturnal symptoms (OR: 0.63; <jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.04) and hiatal hernia (OR: 0.32; <jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001). Compared with PPI\u2010na\u00efve NERD patients, those on PPI were more likely to have nocturnal symptoms (69% vs. 29%, <jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.048) and less likely to have mild\u2010moderate symptoms (63% vs. 79%, <jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001) \u2013 similar to the EO group.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Pre\u2010endoscopy PPI usage contributes significantly to the classification of GERD patients into the NERD\u2010phenotype. NERD patients on PPI therapy demonstrate some features that are significantly different from PPI\u2010na\u00efve patients, but similar to EO patients. This observation supports the notion that some PPI NERD patients are actually healed EO patients, and that an overlap does exist between the GERD phenotypes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2010.04468.x","type":"journal-article","created":{"date-parts":[[2010,9,29]],"date-time":"2010-09-29T04:01:30Z","timestamp":1285732890000},"page":"1266-1274","source":"Crossref","is-referenced-by-count":20,"title":["The impact of pre\u2010endoscopy proton pump inhibitor use on the classification of non\u2010erosive reflux disease and erosive oesophagitis"],"prefix":"10.1111","volume":"32","author":[{"given":"S.","family":"Gaddam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Maddur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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