{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:25:59Z","timestamp":1790972759233,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2010,10,7]],"date-time":"2010-10-07T00:00:00Z","timestamp":1286409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:sec><jats:label\/><jats:p> <jats:italic>Aliment Pharmacol Ther<\/jats:italic> 2010; <jats:bold>32:<\/jats:bold> 1398\u20131404<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Somatostatin analogues are administered to control hormone hypersecretion in acromegaly and carcinoid patients. Somatostatin analogues can increase fat in the stools, which can lead to loss of fat\u2010soluble vitamins. The effect of long\u2010term somatostatin analogue use on vitamin levels remains unknown.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To investigate the prevalence of fat\u2010soluble vitamin deficiencies in long\u2010term somatostatin analogue users.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> All acromegaly and carcinoid patients using somatostatin analogues for \u2265\u200318\u2003months visiting the University Medical Center Groningen between December 2008 and April 2009 were eligible. Vitamin levels of fat\u2010soluble vitamins in blood, clinical and vitamin\u2010dependent laboratory parameters were collected.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In all, 19 acromegaly and 35 carcinoid patients were included. Twelve patients experienced steatorrhoea; two carcinoid patients experienced night blindness. Forty\u2010two (78%) were deficient for one or more vitamins, and 32% (<jats:italic>n<\/jats:italic>\u2003=\u200317) had multiple deficiencies. Deficiencies for vitamin A, D, E, K1 and E in erythrocytes occurred in 6%, 28%, 15%, 63% and 58% of the patients. Prevalence of vitamin D, E and K1 deficiencies was similar in both patient groups. Treatment duration did not influence vitamin levels. The length of intestinal resection and age correlated negatively with vitamin A levels.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Fat\u2010soluble vitamin deficiencies are frequent during long\u2010term somatostatin analogue treatment. Therefore, fat\u2010soluble vitamins should be monitored in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2010.04479.x","type":"journal-article","created":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T01:47:26Z","timestamp":1286502446000},"page":"1398-1404","source":"Crossref","is-referenced-by-count":53,"title":["Deficiencies in fat\u2010soluble vitamins in long\u2010term users of somatostatin analogue"],"prefix":"10.1111","volume":"32","author":[{"given":"H.\u2010B.","family":"Fiebrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Van Den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. P.","family":"Kema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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