{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T18:18:33Z","timestamp":1775845113992,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T00:00:00Z","timestamp":1287360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:sec><jats:label\/><jats:p> <jats:italic>Aliment Pharmacol Ther<\/jats:italic> 2011; <jats:bold>33:<\/jats:bold> 99\u2013105<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Itopride is a new prokinetic agent that combines antidopaminergic and cholinesterase inhibitory actions. Previous studies suggested that itopride improves heartburn in functional dyspepsia, and decreases oesophageal acid exposure in gastro\u2010oesophageal reflux disease. It remains unclear whether this effect is due to effects of itopride on the lower oesophageal sphincter (LES).<\/jats:p><jats:p><jats:bold>Aims\u2002<\/jats:bold> To study the effects of itopride on fasting and postprandial LES function in healthy subjects.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Twelve healthy volunteers (five men; 32.6\u2003\u00b1\u20032.0\u2003years) underwent three oesophageal sleeve manometry studies after 3\u2003days premedication with itopride 50\u2003mg, itopride 100\u2003mg or placebo t.d.s. Drug was administered after 30\u2003min and a standardized meal was administered after 90\u2003min, with measurements continuing to 120\u2003min postprandially. Throughout the study, 10 wet swallows were administered at 30\u2010min intervals, and gastrointestinal symptoms were scored on 100\u2003mm visual analogue scales at 15\u2010min intervals.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Lower oesophageal sphincter resting pressures, swallow\u2010induced relaxations and the amplitude or duration of peristaltic contractions were not altered by both doses of itopride, at all time points. Itopride pre\u2010treatment inhibited the meal\u2010induced rise of transient LES relaxations (TLESRs).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Itopride inhibits TLESRs without significantly affecting oesophageal peristaltic function or LES pressure. These observations support further studies with itopride in gastro\u2010oesophageal reflux disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2010.04487.x","type":"journal-article","created":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T01:16:32Z","timestamp":1287450992000},"page":"99-105","source":"Crossref","is-referenced-by-count":29,"title":["The effects of itopride on oesophageal motility and lower oesophageal sphincter function in man"],"prefix":"10.1111","volume":"33","author":[{"given":"E.","family":"Scarpellini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Vos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Blondeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Boecxstaens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Farr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gasbarrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,10,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.66.317"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.71.129"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.09.001"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.01058.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00869.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052639"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.132449"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i27.4210"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep1160"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.1.6"},{"key":"e_1_2_6_13_2","first-page":"454","article-title":"Recent developments in the pathophysiology and therapy of gastroesophageal reflux disease and nonerosive reflux disease","volume":"21","author":"Tack J","year":"2005","journal-title":"Curr Opin Gastroenterol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2008.08.005"},{"key":"e_1_2_6_15_2","first-page":"G128","article-title":"Criteria for objective definition of transient lower esophageal sphincter relaxation","volume":"268","author":"Holloway RH","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00869.x"},{"key":"e_1_2_6_17_2","first-page":"A688","article-title":"Influence of itopride and domperidone on gastric tone and on the perception of gastric distention in healthy subjects","volume":"132","author":"Akyuz F","year":"2007","journal-title":"Gastroenterology"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000093485"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1993.tb00064.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2005.02422.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01307583"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00883.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.5.603"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70408-2"}],"container-title":["Alimentary Pharmacology &amp; 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