{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:05:26Z","timestamp":1790726726929,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1505,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1111\/j.1365-2036.2011.04775.x","type":"journal-article","created":{"date-parts":[[2011,7,19]],"date-time":"2011-07-19T04:42:41Z","timestamp":1311050561000},"page":"638-648","source":"Crossref","is-referenced-by-count":60,"title":["Randomised clinical trial: the effects of amitriptyline on drinking capacity and symptoms in patients with functional dyspepsia, a double-blind placebo-controlled study"],"prefix":"10.1111","volume":"34","author":[{"given":"B.","family":"Braak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. K.","family":"Klooker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M.","family":"van den Wijngaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. E.","family":"Boeckxstaens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,19]]},"reference":[{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional bowel disorders","volume":"130","author":"Longstreth","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","article-title":"Functional gastroduodenal disorders","volume":"130","author":"Tack","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1136\/gut.2008.163162","article-title":"Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis","volume":"58","author":"Ford","year":"2009","journal-title":"Gut"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/gut.2004.047423","article-title":"Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome","volume":"54","author":"Morgan","year":"2005","journal-title":"Gut"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/j.1440-1746.1998.tb00723.x","article-title":"Symptom relief with amitriptyline in the irritable bowel syndrome","volume":"13","author":"Rajagopalan","year":"1998","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jpeds.2007.10.012","article-title":"Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents","volume":"152","author":"Bahar","year":"2008","journal-title":"J Pediatr"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB7|cit7","first-page":"278","article-title":"Effect of fluoxetine on symptoms and gastric dysrhythmia in patients with functional dyspepsia","volume":"50","author":"Wu","year":"2003","journal-title":"Hepatogastroenterology"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.cgh.2008.02.051","article-title":"Effect of the antidepressant venlafaxine in functional dyspepsia: a randomized, double-blind, placebo-controlled trial","volume":"6","author":"van Kerkhoven","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1572-0241.1998.00160.x","article-title":"Effect of amitriptyline on symptoms, sleep, and visceral perception in patients with functional dyspepsia","volume":"93","author":"Mertz","year":"1998","journal-title":"Am J Gastroenterol"},{"issue":"Suppl 2","key":"10.1111\/j.1365-2036.2011.04775.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1365-2036.2005.02473.x","article-title":"New strategy of therapy for functional dyspepsia using famotidine, mosapride and amitriptyline","volume":"21","author":"Otaka","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1365-2982.2004.00613.x","article-title":"Effects of the selective serotonin reuptake inhibitor, fluoxetine, on regional gastric contractility","volume":"17","author":"James","year":"2005","journal-title":"Neurogastroenterol Motil"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1053\/gast.2001.28656","article-title":"Impaired drinking capacity in patients with functional dyspepsia: relationship with proximal stomach function","volume":"121","author":"Boeckxstaens","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1136\/gut.52.9.1271","article-title":"Assessment of meal induced gastric accommodation by a satiety drinking test in health and in severe functional dyspepsia","volume":"52","author":"Tack","year":"2003","journal-title":"Gut"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1365-2036.1999.00445.x","article-title":"Development of a new dyspepsia impact scale: the Nepean Dyspepsia Index","volume":"13","author":"Talley","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1572-0241.2002.05421.x","article-title":"The proximal stomach and postprandial symptoms in functional dyspeptics","volume":"97","author":"Boeckxstaens","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/j.1365-2982.2007.00971.x","article-title":"Impaired drinking capacity in patients with functional dyspepsia: intragastric distribution and distal stomach volume","volume":"19","author":"van den Elzen","year":"2007","journal-title":"Neurogastroenterol Motil"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00535-006-1818-x","article-title":"Helicobacter pylori eradication versus prokinetics in the treatment of functional dyspepsia: a randomized, double-blind study","volume":"41","author":"Ang","year":"2006","journal-title":"J Gastroenterol"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s11938-001-0057-8","article-title":"Nonulcer Dyspepsia","volume":"4","author":"Boeckxstaens","year":"2001","journal-title":"Curr Treat Options Gastroenterol"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s10620-006-9156-7","article-title":"Proton pump inhibitors: effective first-line treatment for management of dyspepsia","volume":"52","author":"Peura","year":"2007","journal-title":"Dig Dis Sci"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1111\/j.1572-0241.2005.00225.x","article-title":"Guidelines for the management of dyspepsia","volume":"100","author":"Talley","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/archpsyc.1965.01720310065008","article-title":"A Self-Rating Depression Scale","volume":"12","author":"Zung","year":"1965","journal-title":"Arch Gen Psychiatry"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1542-3565(04)00348-9","article-title":"Responsiveness and interpretation of a symptom severity index specific to upper gastrointestinal disorders","volume":"2","author":"Revicki","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s11136-004-9567-x","article-title":"Development and psychometric evaluation of the patient assessment of upper gastrointestinal symptom severity index (PAGI-SYM) in patients with upper gastrointestinal disorders","volume":"13","author":"Rentz","year":"2004","journal-title":"Qual Life Res"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1176\/ajp.137.6.653","article-title":"The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels","volume":"137","author":"Amsterdam","year":"1980","journal-title":"Am J Psychiatry"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1370\/afm.349","article-title":"Efficacy and tolerability of tricyclic antidepressants and SSRIs compared with placebo for treatment of depression in primary care: a meta-analysis","volume":"3","author":"Arroll","year":"2005","journal-title":"Ann Fam Med"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1177\/0269881107088441","article-title":"Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2000 British Association for Psychopharmacology guidelines","volume":"22","author":"Anderson","year":"2008","journal-title":"J Psychopharmacol"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1365-2982.2007.01029.x","article-title":"The effect of short-term, low-dose tricyclic and tetracyclic antidepressant treatment on satiation, postnutrient load gastrointestinal symptoms and gastric emptying: a double-blind, randomized, placebo-controlled trial","volume":"20","author":"Choung","year":"2008","journal-title":"Neurogastroenterol Motil"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s002130000420","article-title":"Acute administration of amitriptyline and mianserin increases dopamine release in the rat nucleus accumbens: possible involvement of serotonin2C receptors","volume":"150","author":"Di Matteo","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1572-0241.2005.30375.x","article-title":"Clinical response to tricyclic antidepressants in functional bowel disorders is not related to dosage","volume":"100","author":"Halpert","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"G612","DOI":"10.1152\/ajpgi.00431.2003","article-title":"Regional gastric contractility alterations in a diabetic gastroparesis mouse model: effects of cholinergic and serotoninergic stimulation","volume":"287","author":"James","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2982.2004.00515.x","article-title":"Effects of clonidine and tricyclic antidepressants on gastric smooth muscle contractility","volume":"16","author":"James","year":"2004","journal-title":"Neurogastroenterol Motil"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB32|cit32","first-page":"G460","article-title":"Differential effects of amitriptyline on perception of somatic and visceral stimulation in healthy humans","volume":"1","author":"Gorelick","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1111\/j.1572-0241.2008.02021.x","article-title":"Effects of amitriptyline on gastric sensorimotor function and postprandial symptoms in healthy individuals: a randomized, double-blind, placebo-controlled trial","volume":"103","author":"Bouras","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000088363","article-title":"Effects of desipramine and escitalopram on postprandial symptoms induced by the nutrient drink test in healthy volunteers: a randomized, double-blind, placebo-controlled study","volume":"72","author":"Talley","year":"2005","journal-title":"Digestion"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1046\/j.1365-2982.2002.00344.x","article-title":"Effect of the selective serotonin reuptake inhibitor sertraline on gastric sensitivity and compliance in healthy humans","volume":"14","author":"Ladabaum","year":"2002","journal-title":"Neurogastroenterol Motil"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2982.2011.01671.x","article-title":"Effect of mianserin on gastric sensorimotor function and gastric emptying: a randomized, placebo-controlled, double-blind, crossover study in healthy volunteers","volume":"23","author":"Janssen","year":"2011","journal-title":"Neurogastroenterol Motil"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1365-2982.2006.00867.x","article-title":"Clinical, psychiatric and manometric profile of cyclic vomiting syndrome in adults and response to tricyclic therapy","volume":"19","author":"Namin","year":"2007","journal-title":"Neurogastroenterol Motil"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ncpgasthep1094","article-title":"Functional nausea and vomiting","volume":"5","author":"Olden","year":"2008","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.giec.2008.12.008","article-title":"Current treatment of nausea and vomiting associated with gastroparesis: antiemetics, prokinetics, tricyclics","volume":"19","author":"Stapleton","year":"2009","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.appet.2007.09.015","article-title":"Why is the neurobiology of nausea and vomiting so important?","volume":"50","author":"Horn","year":"2008","journal-title":"Appetite"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1016\/j.neuroimage.2007.11.008","article-title":"Gastric distention activates satiety circuitry in the human brain","volume":"39","author":"Wang","year":"2008","journal-title":"Neuroimage"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB42|cit42","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000139192","article-title":"Variation in the affinity of amitriptyline for muscarine receptor subtypes","volume":"48","author":"Choi","year":"1994","journal-title":"Pharmacology"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB43|cit43","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0022-3565(25)22639-8","article-title":"Antihistaminic and antimuscarinic effects of amitriptyline on guinea pig ileal electrolyte transport and muscle contractility in vitro","volume":"245","author":"Kachur","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB44|cit44","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2165\/00003495-199243040-00003","article-title":"Pharmacological agents affecting emesis. A review (Part II)","volume":"43","author":"Mitchelson","year":"1992","journal-title":"Drugs"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB45|cit45","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2165\/00003495-199243030-00002","article-title":"Pharmacological agents affecting emesis. A review (Part I)","volume":"43","author":"Mitchelson","year":"1992","journal-title":"Drugs"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB46|cit46","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1365-2982.2006.00779.x","article-title":"Challenges in drug development for functional gastrointestinal disorders. Part II: visceral pain","volume":"18","author":"Andresen","year":"2006","journal-title":"Neurogastroenterol Motil"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB47|cit47","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1365-2125.2007.03052.x","article-title":"Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants","volume":"65","author":"Bijl","year":"2008","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/j.1365-2036.2011.04775.x-BIB48|cit48","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2217\/14622416.6.5.491","article-title":"Pharmacogenomics and functional gastrointestinal disorders","volume":"6","author":"Camilleri","year":"2005","journal-title":"Pharmacogenomics"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2011.04775.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1365-2036.2011.04775.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:35:48Z","timestamp":1741307748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2011.04775.x"}},"subtitle":["Randomised clinical trial: amitriptyline and drinking capacity in functional dyspepsia"],"short-title":[],"issued":{"date-parts":[[2011,7,19]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,9]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2011.04775.x","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13200059.14542232","asserted-by":"object"}]},"ISSN":["0269-2813"],"issn-type":[{"value":"0269-2813","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7,19]]}}}