{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:36:50Z","timestamp":1785908210314,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T00:00:00Z","timestamp":1320796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:italic>Aliment Pharmacol Ther<\/jats:italic>\n                      2012;\n                      <jats:bold>35:<\/jats:bold>\n                      154\u2013164\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>\n                      <jats:bold>Background\u2002<\/jats:bold>\n                      The evolution of gastro\u2010oesophageal reflux disease (GERD) under current management options remains uncertain.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Aim\u2002<\/jats:bold>\n                      To examine whether, depending on the initial presentation, non\u2010erosive (NERD) and erosive reflux disease (ERD) without Barrett\u2019s oesophagus will progress to more severe disease under current routine care following the resolution of the initial condition.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Methods\u2002<\/jats:bold>\n                      Patients with the primary symptom of heartburn were included at baseline, and stratified into non\u2010erosive (NERD) and erosive reflux disease (ERD), LA grades A\u2013D (Los Angeles classification). After a 2\u2010 to 8\u2010week course with esomeprazole therapy to achieve endoscopic healing in ERD and symptom relief in NERD, patients were treated routinely at the discretion of their physician. We report oesophagitis status and the presence of endoscopic and confirmed Barrett\u2019s oesophagus after 5\u2003years.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Results\u2002<\/jats:bold>\n                      A total of 6215 patients were enrolled in the study of whom 2721 patients completed the 5\u2010year follow\u2010up. Progression, regression and stability of GERD severity were followed from baseline to 5\u2003years. Only a few patients with NERD and mild\/moderate ERD progressed to severe forms of ERD and even Barrett\u2019s oesophagus. Most patients remained stable or showed improvement in their oesophagitis; 5.9% of the NERD patients, 12.1% of LA grade A\/B patients and 19.7% of LA grade C\/D patients in whom no Barrett\u2019s oesophagus was recorded at baseline progressed to endoscopic or confirmed Barrett\u2019s oesophagus at 5\u2003years.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Conclusion\u2002<\/jats:bold>\n                      Most GERD patients remain stable or improve over a 5\u2010year observation period under current routine clinical care.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1365-2036.2011.04901.x","type":"journal-article","created":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T20:33:47Z","timestamp":1320870827000},"page":"154-164","source":"Crossref","is-referenced-by-count":136,"title":["Evolution of gastro\u2010oesophageal reflux disease over 5\u2003years under routine medical care \u2013 the ProGERD study"],"prefix":"10.1111","volume":"35","author":[{"given":"P.","family":"Malfertheiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nocon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vieth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Stolte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Jaspersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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