{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T09:49:11Z","timestamp":1781344151357,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T00:00:00Z","timestamp":1322092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:italic>Aliment Pharmacol Ther<\/jats:italic> 2012; <jats:bold>35:<\/jats:bold> #\u2013#<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The consensus statements for eosinophilic oesophagitis recommend that ambulatory pH monitoring is one means of determining if gastro\u2010oesophageal reflux is the cause of oesophageal eosinophilia and should guide pharmacological therapy.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To evaluate prospectively the accuracy of pH monitoring as a predictor of endoscopic, histological and symptomatic response in patients with oesophageal eosinophilia.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We conducted a prospective trial in which patients with oesophageal eosinophilic infiltration with \u226515 eos\/hpf underwent a 24\u2010h pH study and were placed in one of two treatment arms for 6\u2003weeks based on positive or negative results. Patients with abnormal acid exposure were treated with esomeprazole 40\u2003mg twice daily and others were treated with oral viscous budesonide 1\u2003g twice daily. Response to treatment was assessed by oesophageal histology (&lt;5\u2003eos\/hpf) and symptoms.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A total of 51 patients were enrolled in the study. The average patient age was 39\u2003years and 31 patients (61%) were male. The average number of eosinophils per hpf, prior to study enrolment was 41.2 (range 15\u2013140, s.d. 27.7). Nineteen (37%) had positive pH studies and 32 (63%) had negative pH studies. Eighteen patients completed treatment with esomeprazole. Only eleven (61%) had histological response and, of these eleven, five (46%) had symptomatic improvement. A total of 28 patients with normal acid exposure completed treatment with budesonide. Only 16 (57%) had histological and 11 (69%) had symptomatic improvement.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> In this prospective trial of pH\u2010guided treatment, neither positive nor negative results of initial pH monitoring accurately predicted response to therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2011.04922.x","type":"journal-article","created":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T07:39:12Z","timestamp":1322120352000},"page":"300-307","source":"Crossref","is-referenced-by-count":84,"title":["Results of ambulatory pH monitoring do not reliably predict response to therapy in patients with eosinophilic oesophagitis"],"prefix":"10.1111","volume":"35","author":[{"given":"D. L.","family":"Francis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Foxx\u2010Orenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. C.","family":"Smyrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L.","family":"Nord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Katzka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04411.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.06.023"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.04.037"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.017"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.5858\/134.6.815"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.08.030"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01594.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.040"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2007.00670.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-009-9246-8"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.05.001"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0859-4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.468"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.09.019"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01179.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.40"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.06.023"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2011.04922.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2011.04922.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T13:23:44Z","timestamp":1698758624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2011.04922.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,24]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1111\/j.1365-2036.2011.04922.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2011.04922.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,24]]}}}