{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:32:04Z","timestamp":1773307924297,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T00:00:00Z","timestamp":1324512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Adalimumab is effective for the induction and maintenance of remission in Crohn\u2019s disease (CD)\u2010patients.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To find predictors for adalimumab dose escalation at initiation of adalimumab.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Crohn\u2019s disease patients in a single tertiary referral centre who started adalimumab between July 2007 and March 2010 at an induction dose (week 0 160\u2003mg subcutaneously (sc), week 2 80\u2003mg sc) and maintenance dose of 40\u2003mg sc thereafter every other week were followed prospectively. Patients on adalimumab for at least 3\u2003months were included. The number of patients needing dose escalation was assessed. Patients that needed dose escalation were compared with patients that did not need dose escalation.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Of 199 CD patients treated with adalimumab and followed prospectively, 122 patients (M\/F 54\/68, median age 35\u2003years, range 18\u201366\u2003years, median CDAI 164, range 6\u2013468) were treated for 3\u2003months. In total 38% of these patients (46\/122) needed a dose escalation within a median time of 21\u2003weeks after adalimumab introduction (range 4\u2013105). Body mass index (BMI) (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.03) and secondary non\u2010response to infliximab (IFX) (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.06) were identified as predictors for dose escalation. Concomitant use of immunomodulators at initiation of adalimumab and the presence of autoantibodies to IFX did not predict dose escalation.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Over one\u2010third adalimumab\u2010treated patients are dose escalated within a median of 5\u2003months. Higher BMI and secondary non\u2010response to IFX treatment are predictive for a dose escalation during adalimumab treatment.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2011.04946.x","type":"journal-article","created":{"date-parts":[[2011,12,23]],"date-time":"2011-12-23T03:16:47Z","timestamp":1324610207000},"page":"335-341","source":"Crossref","is-referenced-by-count":96,"title":["Predictors of dose escalation of adalimumab in a prospective cohort of Crohn\u2019s disease patients"],"prefix":"10.1111","volume":"35","author":[{"given":"E.","family":"Bultman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"de Haar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"van Liere\u2010Baron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Verhoog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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