{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:48:15Z","timestamp":1792435695887,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T00:00:00Z","timestamp":1326153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Visceral tone supposedly affects gut sensitivity in irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>). Sildenafil increases nitric oxide and influences visceral compliance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the effects of sildenafil tone inhibition on rectal sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight controls and 21 IBS patients (Rome II) were enrolled in a double\u2010blind study, after dosing with placebo or sildenafil (50\u00a0mg <jats:italic>p.o<\/jats:italic>.). Thresholds for first sensation, first desire to defecate, pain and supraliminar pain were the sensory endpoints, measured with a barostat and 600\u2010<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> rectal bag. Pain (100\u2010mm VAS) and depression\u2010anxiety (Hamilton questionnaire) were scored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Irritable bowel syndrome rectal compliance and sensory\u2010endpoint thresholds were similar to controls. Five IBS patients had pain threshold lower than controls 95% confidence interval (hypersensitive). Depression score was greater in IBS than controls (11.9\u00a0\u00b1\u00a01.3 vs. 6.3\u00a0\u00b1\u00a02.5, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.036). In IBS, pain intensity was nonsignificantly higher (37.6\u00a0\u00b1\u00a05.3\u00a0mm vs. 23.4\u00a0\u00b1\u00a08.5\u00a0mm, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.064) and supraliminar pain intensity was greater (45.6\u00a0\u00b1\u00a05.4\u00a0mm vs. 25.9\u00a0\u00b1\u00a05.1\u00a0mm, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.044) than controls. IBS rectal relaxation increased volume (155.4\u00a0\u00b1\u00a041.3\u00a0mL vs. 118.8\u00a0\u00b1\u00a047.7\u00a0mL, <jats:italic>P<\/jats:italic>\u00a0= 0.004) and tension (193.1\u00a0\u00b1\u00a0118.6\u00a0mmHg\u00a0mL<jats:sup>\u22121<\/jats:sup> vs. 133.2\u00a0\u00b1\u00a098.1\u00a0mmHg\u00a0mL<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0= 0.019) for triggering first desire to defecate but not for other perceptions. Sildenafil increased volume for both first desire to defecate and pain in the hypersensitive IBS patients. Sildenafil increased rectal compliance only in diarrhoea\u2010IBS. Mixed\u2010IBS obtained higher anxiety (12.9\u00a0\u00b1\u00a01.3 vs. 5.9\u00a0\u00b1\u00a03.1, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and depression scores (13.9\u00a0\u00b1\u00a01.9 vs. 6.3\u00a0\u00b1\u00a02.5, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and reported more intense supraliminar pain (53.6\u00a0\u00b1 9.8\u00a0mm vs. 25.9\u00a0\u00b1\u00a05.1\u00a0mm, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) than controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Rectal relaxation following dosing with sildenafil 50 mg increased the first desire to defecate threshold in <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> as a whole, but decreased pain only in the hypersensitive subset. Mixed\u2010<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> presented higher supraliminar pain and anxiety\u2010depression scores.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2011.04977.x","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T07:56:13Z","timestamp":1326182173000},"page":"577-586","source":"Crossref","is-referenced-by-count":8,"title":["The effects of sildenafil on rectal sensitivity and tone in patients with the irritable bowel syndrome"],"prefix":"10.1111","volume":"35","author":[{"given":"M. T.","family":"Gon\u00e7alves de Medeiros","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Federal University of Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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