{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:32:12Z","timestamp":1761708732641},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T00:00:00Z","timestamp":1329868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Approximately 30\u201340% of patients with <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>arrett's oesophagus (<jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>) patients manifest abnormal oesophageal <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> profiles despite proton pump inhibitor (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>) therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine control of oesophageal reflux using <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ravo <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> monitoring in patients <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content> on omeprazole\u2010sodium bicarbonate oral suspension powder (<jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>me\u2010<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>a<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ic) 40\u00a0mg twice daily.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Initial <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> monitoring off <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> for 1\u00a0week was performed. All patients underwent repeat <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> testing on <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>me\u2010<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>a<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ic administered before breakfast and at bedtime after 21\u201328\u00a0days of therapy depending upon the prior <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> therapy. The goal was to enroll 30 subjects, however, the trial was terminated prematurely when the sponsor lost financing due to a change in business strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 88 patients responded to the study invitation, 27 patients signed informed consent, and 21 patients underwent <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> testing of <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>. A total of 15 patients completed the protocol (13 men, 2 women). Demographic information for patients completing at least one <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ravo study included a mean (\u00b1s.d.) age 62\u00a0\u00b1\u00a09\u00a0years; body mass index 31\u00a0\u00b1\u00a08 kg\/m<jats:sup>2<\/jats:sup> (range 23\u201348); mean <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content> length of 2.6\u00a0\u00b1\u00a02\u00a0cm; 9 (43%) patients with long segment <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>. All (100%) patients demonstrated normalisation of supine <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> on both days of <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>me\u2010<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>a<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ic therapy. One patient (6%) demonstrated abnormal upright reflux on the second day of monitoring on <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>me\u2010<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>a<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ic therapy; all the other patients demonstrated normal <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> scores on therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Administration of twice daily <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>me\u2010<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>a<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ic demonstrated control of nocturnal oesophageal reflux in 100% of patients with Barrett's oesophagus, and complete control of oesophageal <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> during 97% of the 24\u2010h recording periods.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05016.x","type":"journal-article","created":{"date-parts":[[2012,2,23]],"date-time":"2012-02-23T03:16:21Z","timestamp":1329966981000},"page":"803-809","source":"Crossref","is-referenced-by-count":13,"title":["Control of intra\u2010oesophageal <scp>pH<\/scp> in patients with <scp>B<\/scp>arrett's oesophagus on omeprazole\u2010sodium bicarbonate therapy"],"prefix":"10.1111","volume":"35","author":[{"given":"L. 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