{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T16:56:14Z","timestamp":1775580974425,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T00:00:00Z","timestamp":1329782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peptic ulcer bleeding remains a major healthcare problem despite decreasing prevalence of peptic ulcer disease. The role of chronic obstructive pulmonary disease (<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>) in the risk of peptic ulcer bleeding has not yet been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine if <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> patients have a higher risk of peptic ulcer bleeding than the general population and to identify the risk factors of peptic ulcer bleeding in <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From Taiwan's National Health Insurance research database, 62\u00a0876 patients, including 32\u00a0682 <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> and 30\u00a0194 age\u2010gender\u2010matched non\u2010<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> controls, were recruited. Cox proportional hazard regression was performed to evaluate independent risk factors for ulcer bleeding in all patients and to identify risk factors in <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the 8\u2010year follow\u2010up, <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> patients had a significant higher rate of peptic ulcer bleeding than the control group (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001, by log\u2010rank test). By Cox proportional hazard regression analysis, <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> [hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) 1.93, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.73\u20132.17] was an independent risk factor after adjusting for age, gender, underlying comorbidities and ulcerogenic medication. Age\u00a0&gt;\u00a065\u00a0years, male, comorbidities of hypertension, diabetes, heart failure, history of peptic ulcer disease, and chronic renal disease and use of nonsteroidal anti\u2010inflammatory drugs were risk factors of ulcer bleeding in <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with chronic obstructive pulmonary disease have a higher risk of peptic ulcer bleeding after adjustments for possible confounding factors like underlying comorbidities and ulcerogenic medication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05028.x","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T07:16:13Z","timestamp":1329808573000},"page":"796-802","source":"Crossref","is-referenced-by-count":42,"title":["Chronic obstructive pulmonary disease: an independent risk factor for peptic ulcer bleeding: a nationwide population\u2010based study"],"prefix":"10.1111","volume":"35","author":[{"given":"K.\u2010W.","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Medicine National Yang\u2010Ming University School of Medicine Taipei Taiwan"},{"name":"Division of Gastroenterology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010C.","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Medicine National Yang\u2010Ming University School of Medicine Taipei Taiwan"},{"name":"Division of Gastroenterology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010B.","family":"Leu","sequence":"additional","affiliation":[{"name":"Department of Medicine National Yang\u2010Ming University School of Medicine Taipei Taiwan"},{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital 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