{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:03:41Z","timestamp":1791644621761,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The optimal dosage of intravenous proton pump inhibitors (\n                      <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\n                      s) for the prevention of peptic ulcer rebleeding remains unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To compare the rebleeding rate of high\u2010dose and standard\u2010dose\n                      <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\n                      use after endoscopic haemostasis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 201 patients with bleeding ulcers undergoing endoscopic treatment with epinephrine injection and heater probe thermocoagulation were randomised to receive a high\u2010dose regimen (80\u00a0mg bolus, followed by pantoprazole 8\u00a0mg\/h infusion,\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\u00a0100) or a standard\u2010dose regimen (pantoprazole 40\u00a0mg bolus daily,\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\u00a0101). After 72\u00a0h, all patients were given 40\u00a0mg pantoprazole daily orally for 27\u00a0days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no statistical differences in mean units of blood transfused, length of hospitalisation \u22665\u00a0days, surgical or radiological interventions and mortality within 30\u00a0days between two groups. Bleeding recurred within 30\u00a0days in six patients [6.2%, 95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ) 1.3\u201311.1%] in the high\u2010dose group, as compared to five patients (5.2%, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.6\u20139.7%) in the standard\u2010dose group (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.77). The stepwise Cox regression analysis showed end\u2010stage renal disease, haematemesis, chronic obstructive pulmonary disease (hazard ratio: 37.15, 10.07, 9.12, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 6.76\u2013204.14, 2.07\u201349.01, 1.66\u201350.00 respectively) were independent risk factors for rebleeding and\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection was associated with lower risk of rebleeding (hazard ratio: 0.20, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.04\u20130.94).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Following combined endoscopic haemostasis of bleeding ulcers, co\u2010morbidities, haematemesis and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      Status, but not\n                      <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\n                      dosage, are associated with rebleeding (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.Clinical Trials.gov\">http:\/\/www.Clinical Trials.gov<\/jats:ext-link>\n                      .\n                      <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>\n                      :\n                      <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n                      00709046).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05047.x","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T04:45:54Z","timestamp":1330404354000},"page":"894-903","source":"Crossref","is-referenced-by-count":31,"title":["Randomised clinical trial: high\u2010dose vs. standard\u2010dose proton pump inhibitors for the prevention of recurrent haemorrhage after combined endoscopic haemostasis of bleeding peptic ulcers"],"prefix":"10.1111","volume":"35","author":[{"given":"C.\u2010C.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Yun\u2010Lin Branch Douliou Taiwan"},{"name":"Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Yun\u2010Lin Branch Douliou Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010J.","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Yun\u2010Lin Branch Douliou Taiwan"},{"name":"Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010J.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Yun\u2010Lin Branch Douliou Taiwan"},{"name":"Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010l.","family":"Han","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan"},{"name":"Department of Internal Medicine Min\u2010Sheng General Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.\u2010H.","family":"Tseng","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University College of Medicine and National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010M.","family":"Liou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University College of Medicine and National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.\u2010C.","family":"Hu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.\u2010l.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University College of Medicine and National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010S.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University College of Medicine and National Taiwan University Hospital Taipei Taiwan"},{"name":"Department of Primary Care Medicine National Taiwan University College of Medicine and National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010P.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University College of Medicine and National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010T.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University College of Medicine and National Taiwan University Hospital Taipei Taiwan"},{"name":"Department of Internal Medicine E\u2010 DA Hospital and I\u2010Shou University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00208.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30272.x"},{"issue":"4","key":"e_1_2_6_4_1","first-page":"1","article-title":"Non\u2010variceal upper gastrointestinal haemorrhage: guidelines","volume":"51","author":"British Society of Gastroenterology Endoscopy Committee","year":"2002","journal-title":"Gut"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-2-201001190-00009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.01023.x"},{"key":"e_1_2_6_7_1","first-page":"CD005584","article-title":"Epinephrine injection versus epinephrine injection and a second endoscopic method in high risk bleeding ulcers","author":"Vergara M","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_8_1","first-page":"CD002094","article-title":"Proton pump inhibitor treatment for acute peptic ulcer bleeding","author":"Leontiadis GI","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(78)90352-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008033430501"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-7-200904070-00105"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00399.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05939.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655201317097218"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02149.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000158227"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-2759-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2007.04185.x"},{"key":"e_1_2_6_19_1","first-page":"CD002094","article-title":"Proton pump inhibitor treatment for acute peptic ulcer bleeding","author":"Leontiadis GI","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.100"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.04942.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03286.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7420"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-10-200311180-00012"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.08.016"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7420"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.05.031"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.4.324"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00531.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05939.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.3.322"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.3.316"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02070.x"},{"key":"e_1_2_6_34_1","first-page":"2270","article-title":"Increased risk of rebleeding of peptic ulcer bleeding in patients with comorbid illness receiving omeprazole infusion","volume":"50","author":"Cheng HC","year":"2003","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17951"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.224329"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.04.014"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04049.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.08.044"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2012.05047.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2012.05047.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T06:26:01Z","timestamp":1698733561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2012.05047.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,28]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1111\/j.1365-2036.2012.05047.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2012.05047.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.714247817.789652845","asserted-by":"object"}]},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,28]]}}}