{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T18:22:26Z","timestamp":1763662946641},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In some cases, <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic> infection persists even after three eradication treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy of an empirical fourth\u2010line rescue regimen with rifabutin in patients with three eradication failures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>Design<\/jats:italic>: Multicentre, prospective study. <jats:italic>Patients<\/jats:italic>: In whom the following three treatments had consecutively failed: first (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u00a0+\u00a0clarithromycin\u00a0+\u00a0amoxicillin); second (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u00a0+\u00a0bismuth\u00a0+\u00a0tetracycline\u00a0+\u00a0metronidazole); third (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u00a0+\u00a0amoxicillin\u00a0+\u00a0levofloxacin). <jats:italic>Intervention<\/jats:italic>: A fourth regimen with rifabutin (150\u00a0mg b.d.), amoxicillin (1\u00a0g b.d.) and a <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> (standard dose b.d.) was prescribed for 10\u00a0days. <jats:italic>Outcome<\/jats:italic>: Eradication was confirmed by <jats:sup>13<\/jats:sup>C\u2010urea breath test 4\u20138\u00a0weeks after therapy. <jats:italic>Compliance and tolerance<\/jats:italic>: Compliance was determined through questioning and recovery of empty medication envelopes. Adverse effects were evaluated using a questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010hundred patients (mean age 50\u00a0years, 39% men, 31% peptic ulcer\/69% functional dyspepsia) were included. Eight patients did not take the medication correctly (in six cases due to adverse effects). Per\u2010protocol and intention\u2010to\u2010treat eradication rates were 52% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a041\u201363%) and 50% (40\u201360%). Adverse effects were reported in 30 (30%) patients: nausea\/vomiting (13 patients), asthenia\/anorexia (8), abdominal pain (7), diarrhoea (5), fever (4), metallic taste (4), myalgia (4), hypertransaminasemia (2), leucopenia (&lt;1,500 neutrophils) (2), thrombopenia (&lt;150\u00a0000 platelets) (2), headache (1) and aphthous stomatitis (1). Myelotoxicity resolved spontaneously in all cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Even after three previous <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>. pylori<\/jats:italic> eradication failures, an empirical fourth\u2010line rescue treatment with rifabutin may be effective in approximately 50% of the cases. Therefore, rifabutin\u2010based rescue therapy constitutes a valid strategy after multiple previous eradication failures with key antibiotics, such as clarithromycin, metronidazole, tetracycline and levofloxacin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05053.x","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T01:08:18Z","timestamp":1330477698000},"page":"941-947","source":"Crossref","is-referenced-by-count":52,"title":["Fourth\u2010line rescue therapy with rifabutin in patients with three <i>Helicobacter pylori<\/i> eradication failures"],"prefix":"10.1111","volume":"35","author":[{"given":"J. P.","family":"Gisbert","sequence":"first","affiliation":[{"name":"Gastroenterology Department Hospital de La Princesa and Instituto de Investigaci\u00f3n Sanitaria Princesa (IP) Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Castro\u2010Fernandez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Spain"},{"name":"Gastroenterology Department Hospital de Valme Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Perez\u2010Aisa","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Agencia Sanitaria Costa del Sol M\u00e1laga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cosme","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Spain"},{"name":"Gastroenterology Department Hospital de Donostia San Sebasti\u00e1n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Molina\u2010Infante","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital de San Pedro de Alc\u00e1ntara C\u00e1ceres Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital Central de Asturias Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Modolell","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Consorci Sanitari de Terassa Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Cabriada","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital de Galdakao Vizcaya Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Gisbert","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital de La Princesa and Instituto de Investigaci\u00f3n Sanitaria Princesa (IP) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lamas","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Spain"},{"name":"Gastroenterology Department Hospital de Valme Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Marcos","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital de La Princesa and Instituto de Investigaci\u00f3n Sanitaria Princesa (IP) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Calvet","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Spain"},{"name":"Gastroenterology Department Hospital de Sabadell Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1001110"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01276.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.101634"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(03)00081-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.5135"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02737.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2005.00324.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04937.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.5.1568-1571.2001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.5.1072"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.6.1497"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199447060-00008"},{"key":"e_1_2_6_14_1","volume-title":"Abstract Book of the 6th International Congress ofr Infectious Diseases (ICID)","author":"Rossi R","year":"1994"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.Supplement_1.S3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464170-00003"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1083-4389.2004.00195.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00457.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200010000-00007"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00909.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03573.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00588.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00719.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03531.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/637908"},{"key":"e_1_2_6_26_1","first-page":"409","article-title":"Worldwide H. pylori antibiotic resistance: a systematic review","volume":"19","author":"De Francesco V","year":"2010","journal-title":"J Gastrointestin Liver Dis"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01900.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-1-7"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01459.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2004.09.008"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02793.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02993.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.4321\/S1130-01082009000600004"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03452.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-7-31"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02210.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03149.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)65109-4"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.3.594"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2003.00128.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200503-417OC"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1086\/430377"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2012.05053.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2012.05053.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T10:25:40Z","timestamp":1698747940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2012.05053.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,28]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1111\/j.1365-2036.2012.05053.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2012.05053.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,28]]}}}