{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:06:40Z","timestamp":1775243200110,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T00:00:00Z","timestamp":1332201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Baclofen, a <jats:styled-content style=\"fixed-case\">GABA<jats:sub>B<\/jats:sub><\/jats:styled-content> agonist, has been shown to reduce transient lower oesophageal sphincter relaxations (<jats:styled-content style=\"fixed-case\">TLESRs<\/jats:styled-content>), a major cause of gastro\u2010oesophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the effect and tolerability of baclofen in <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> patients over a 2\u2010week period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010three GERD patients with abnormal 24\u2010h <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> tests were prospectively randomised to receive baclofen or placebo in a double\u2010blind fashion for 2\u00a0weeks. Oesophageal manometry, 24\u2010h <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> monitoring, and a standard questionnaire was administered, before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010four patients completed the study. In the baclofen group there were significant decreases in 24\u2010h <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> score (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.020), percent of upright reflux episodes (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.016), percent total time <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> &lt;4 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003), number of reflux episodes (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.018), number of reflux episodes longer than 5\u00a0min (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.016), number of postprandial reflux episodes (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.045), and percentage of time <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> &lt;4 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). No significant changes in reflux parameters were noted in the placebo group. Patients receiving baclofen had significantly less belching (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.038), regurgitation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.036) and overall symptom score (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) whereas placebo patients had less heartburn (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), chest pain (<jats:italic>P<\/jats:italic>\u00a0= 0.002), regurgitation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.017) and overall symptom score (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.000). However, there were no significant differences in changes of reflux parameters or symptoms when comparing the two groups. Drowsiness did not limit baclofen use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Baclofen was associated with a significant decrease in percent upright reflux by 24\u2010h <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> monitoring and a significant improvement in belching, regurgitation and overall symptom score. Baclofen may be more effective in patients with predominantly upright reflux and belching.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05068.x","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T06:49:41Z","timestamp":1332226181000},"page":"1036-1044","source":"Crossref","is-referenced-by-count":65,"title":["Randomised clinical trial: the effect of baclofen in patients with gastro\u2010oesophageal reflux \u2010 a randomised prospective study"],"prefix":"10.1111","volume":"35","author":[{"given":"M. J.","family":"Cossentino","sequence":"first","affiliation":[{"name":"Walter Reed National Military Medical Center Department of Gastroenterology Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Mann","sequence":"additional","affiliation":[{"name":"Walter Reed National Military Medical Center Department of Gastroenterology Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. P.","family":"Armbruster","sequence":"additional","affiliation":[{"name":"Walter Reed National Military Medical Center Department of Gastroenterology Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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