{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:20:50Z","timestamp":1789132850593,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T00:00:00Z","timestamp":1332201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The contribution of hereditary factors to the development of diverticular disease (<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>) of the colon is unknown. Prevalence and location of diverticula differ in Western world compared to in Asia and several case reports describing families with <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> have been published.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the heritability of <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> in a large population\u2010based sample of twins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Swedish Twin Registry was cross\u2010linked to the Swedish Inpatient Registry. All twins, born between 1886 and 1980 and not dead before 1969, with a discharge diagnosis of <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> were identified. Twins with diagnoses of colon cancer, coeliac disease or non\u2010infectious colitis were excluded to decrease bias. Co\u2010twin odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>), concordance rates and tetrachoric correlations were calculated for monozygotic (<jats:styled-content style=\"fixed-case\">MZ<\/jats:styled-content>) and same gender\u2010dizygotic (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DZ<\/jats:styled-content>) twins. <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>x\u2010analyses were used to estimate the relative contributions of genetic effects and environmental factors to susceptibility for <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>. Calculations were based on both primary and secondary discharge diagnoses to provide estimates reflecting impact of severity of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 104\u00a0452 twins met the inclusion criteria. Of these, 2296 had a diagnosis of <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>. The <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> of developing the disease given one's co\u2010twin was affected was 7.15 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 4.82\u201310.61) for <jats:styled-content style=\"fixed-case\">MZ<\/jats:styled-content> and 3.20 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.21\u20134.63) for <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DZ<\/jats:styled-content> twins. Similarly, concordance rates and tetrachoric correlations were higher in <jats:styled-content style=\"fixed-case\">MZ<\/jats:styled-content> than those in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DZ<\/jats:styled-content> twins. The heritability was estimated to 40% and the non shared environmental effects to 60%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Genetic susceptibility is an important component, along with individual specific environmental factors, for the development of diverticular disease of the colon.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05069.x","type":"journal-article","created":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T15:58:33Z","timestamp":1332431913000},"page":"1103-1107","source":"Crossref","is-referenced-by-count":128,"title":["The genetic influence on diverticular disease \u2013 a twin study"],"prefix":"10.1111","volume":"35","author":[{"given":"J.","family":"Granlund","sequence":"first","affiliation":[{"name":"Unit of Gastroenterology and Hepatology Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Svensson","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Department of Medicine, Solna, Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Ol\u00e9n","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Department of Medicine, Solna, Karolinska Institutet Stockholm Sweden"},{"name":"Sachs' Children's Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Hjern","sequence":"additional","affiliation":[{"name":"Division of Surgery Department of Clinical Sciences Danderyd Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. L.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"The Swedish Twin Registry, Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. K. E.","family":"Magnusson","sequence":"additional","affiliation":[{"name":"The Swedish Twin Registry, Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Thelin Schmidt","sequence":"additional","affiliation":[{"name":"Unit of Gastroenterology and Hepatology Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,20]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Aspects on Diverticular Disease [Dissertation]","author":"Hjern F","year":"2006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236634"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5759.450"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7477"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.121"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-9172-5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02896.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.2479"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194609000-00003"},{"key":"e_1_2_6_11_1","first-page":"947","article-title":"Perforierende sigmadivertikulitis bei eineiigen zwillingen","volume":"121","author":"Pusch HH","year":"1979","journal-title":"Munch Med Wochenschr"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308207"},{"key":"e_1_2_6_13_1","first-page":"656","article-title":"Diverticulosis and diverticular disease (reference to a case of diverticular disease observed in 3 sisters)","volume":"37","author":"Vigoni A","year":"1985","journal-title":"Chir Ital"},{"key":"e_1_2_6_14_1","first-page":"54","article-title":"Diverticula of the colon in three Nigerian siblings","volume":"40","author":"Omojola MF","year":"1988","journal-title":"Trop Geogr Med"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-004-0702-5"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-2-202"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2002.01032.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-009-9350-y"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-450"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802247664"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/18.2.171"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1965.tb00500.x"},{"key":"e_1_2_6_23_1","volume-title":"Mx: Statistical Modeling","author":"Neale MC","year":"2006"},{"key":"e_1_2_6_24_1","volume-title":"Introduction to Quantitative Genetics","author":"Falconer DS","year":"1996"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/60.5.757"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02805.x"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2012.05069.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2012.05069.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T19:58:38Z","timestamp":1700596718000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2012.05069.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,20]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1365-2036.2012.05069.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2012.05069.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,20]]}}}