{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:42:40Z","timestamp":1792028560634,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T00:00:00Z","timestamp":1332806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Malnutrition and jaundice are independent prognostic factors in cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the impact of enteral nutrition on the survival of alcoholic cirrhotic patients with jaundice but without acute alcoholic hepatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was a multicentre prospective randomised controlled trial comparing effects of <jats:styled-content style=\"fixed-case\">enteral nutrition<\/jats:styled-content> vs. a symptomatic support in patients with alcoholic cirrhosis and jaundice (bilirubin \u226551\u00a0\u00b5mol\/L) but without severe acute alcoholic hepatitis. A total of 99 patients were randomised to receive either the conventional symptomatic treatment (55 patients) or the symptomatic support associated with 35\u00a0kcal\/Kg\/day of <jats:styled-content style=\"fixed-case\">enteral nutrition<\/jats:styled-content> during 4\u00a0weeks followed by an oral nutritional support during 2\u00a0months (44 patients). Randomisation was stratified on nutritional status. One\u2010year survival curves were compared using the <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier method and <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ogrank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Populations in both arms were similar. One\u2010year survival was similar in the overall population (27\/44 patients (61.4%) in the <jats:styled-content style=\"fixed-case\">enteral nutrition<\/jats:styled-content> arm vs. 36\/55 (65.5%) in the control arm; <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ogrank <jats:italic>P\u00a0<\/jats:italic>=\u00a00.60) and in the subgroup suffering from malnutrition [18\/29 patients (62.1%) in the <jats:styled-content style=\"fixed-case\">enteral nutrition<\/jats:styled-content> arm vs. 20\/32 (62.5%) in the control arm; <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ogrank <jats:italic>P<\/jats:italic>\u00a0=\u00a00.99]. There was no statistical difference for bilirubin, prothrombin rate, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hild\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ugh score, albumin or nutritional assessment. Complications during treatment (bleeding, encephalopathy, infection) occurred in 23% of patients in the <jats:styled-content style=\"fixed-case\">enteral nutrition<\/jats:styled-content> group (10\/44) vs. 16% (9\/55) of the control patients (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.59).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Enteral nutrition does not improve the survival and hepatic or nutritional parameters of cirrhotic patients with jaundice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05075.x","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T15:05:16Z","timestamp":1332860716000},"page":"1166-1174","source":"Crossref","is-referenced-by-count":43,"title":["Randomised clinical trial: enteral nutrition does not improve the long\u2010term outcome of alcoholic cirrhotic patients with jaundice"],"prefix":"10.1111","volume":"35","author":[{"given":"B.","family":"Dupont","sequence":"first","affiliation":[{"name":"Department of Hepato\u2010Gastroenterology and Nutrition Caen University Hospital Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Dao","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Gastroenterology and Nutrition Caen University Hospital Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Joubert","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Gastroenterology and Nutrition Caen University Hospital Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dupont\u2010Lucas","sequence":"additional","affiliation":[{"name":"Department of Statistics Caen University Hospital Caen 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