{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T13:57:53Z","timestamp":1792936673671,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,4,2]],"date-time":"2012-04-02T00:00:00Z","timestamp":1333324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasiform lesions associated with anti\u2010tumour necrosis factor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>) therapy are frequent in patients with inflammatory bowel disease (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>). While methotrexate is the most frequently used systemic treatment for psoriasis, its efficacy for psoriasiform lesions related to anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> therapy remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the efficacy of methotrexate for psoriasiform lesions associated with anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> therapy refractory to topical therapy in <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The charts of eight patients from the Nancy <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> cohort who developed psoriasiform lesions on anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> therapy were reviewed. Clinical response was defined as a decrease of more than 50% in the lesions covering surface. All patients were followed up by the same experienced dermatologist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight women (seven Crohn's disease) were followed up for a median duration of 29\u00a0months (range, 20\u201345). Of the eight patients receiving methotrexate, three were primary responders without discontinuation of anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> agents. Only one patient had a sustained response at final follow\u2010up and was able to continue both methotrexate and anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> therapy. Of the two other primary responders, one patient had to discontinue anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> because of severe psoriasiform lesions, whereas the other one continued anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> therapy despite persistent skin lesions at final follow\u2010up. Among the five primary nonresponders, four patients had to stop anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> treatment due to disabling skin lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Methotrexate does not appear effective in treating psoriasiform lesions associated with anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> therapy refractory to topical therapy in <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05082.x","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T18:14:32Z","timestamp":1333476872000},"page":"1175-1180","source":"Crossref","is-referenced-by-count":21,"title":["Methotrexate for psoriasiform lesions associated with anti\u2010tumour necrosis factor therapy in inflammatory bowel disease"],"prefix":"10.1111","volume":"35","author":[{"given":"A.","family":"Buisson","sequence":"first","affiliation":[{"name":"Department of Hepato\u2010Gastroenterology University Hospital Estaing of Clermont\u2010Ferrand, Universit\u00e9 d'Auvergne Clermont\u2010Ferrand France"},{"name":"Microbes, intestine, inflammation and susceptibility of the host UMR Inserm\/Universit\u00e9 d'Auvergne U1071, Clermont Universit\u00e9 Clermont\u2010Ferrand France"},{"name":"Inserm U954 and Department of Hepato\u2010Gastroenterology University Hospital of Nancy, Universit\u00e9 HenriPoincar\u00e9 1 Vandoeuvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010F.","family":"Cuny","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Nancy, Universit\u00e9 Henri Poincar\u00e9 1 Vandoeuvre\u2010l\u00e8s\u2010Nancy 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