{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:50:59Z","timestamp":1785775859660,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,4,8]],"date-time":"2012-04-08T00:00:00Z","timestamp":1333843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastro\u2010oesophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>), functional dyspepsia (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>) and irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>) are highly prevalent gastrointestinal conditions with accumulating evidence of overlap in patients. Despite availability of a vast body of research related to individual disorders, major pharmacological breakthrough in treatment of the overlap condition is still lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess sustainability of <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> healing and whether known beneficial effects of proton pump inhibitor treatment on <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> also extend to symptoms suggestive of <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 626 patients with reflux oesophagitis were treated with pantoprazole for up to 16\u00a0weeks depending on healing of <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>, followed by an observational phase of up to 6\u00a0months without treatment. Rates of patients suffering from <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FD<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> were assessed at baseline, and at last visits of treatment and observational phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rates of patients with reflux oesophagitis and concomitantly with reflux symptoms, <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> were each significantly lower after pantoprazole treatment (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001). While rates of patients with reflux signs or symptoms increased again during observational phase, rates of <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> were maintained at the low level after cessation of medication (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pantoprazole is efficacious in the treatment of patients suffering from signs and symptoms suggesting an overlap of <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FD<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>, providing a sustained response post\u2010treatment in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> symptom categories. Mechanisms underlying the beneficial effects of improvement in reflux oesophagitis on symptoms suggestive of <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> still need to be determined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05085.x","type":"journal-article","created":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T00:53:40Z","timestamp":1333932820000},"page":"1279-1289","source":"Crossref","is-referenced-by-count":31,"title":["Randomised clinical trial: sustained response to PPI treatment of symptoms resembling functional dyspepsia and irritable bowel syndrome in patients suffering from an overlap with erosive gastro\u2010oesophageal reflux disease"],"prefix":"10.1111","volume":"35","author":[{"given":"H.","family":"M\u00f6nnikes","sequence":"first","affiliation":[{"name":"Department of Medicine Martin\u2010Luther\u2010Hospital Academic Teaching Hospital of Charit\u00e9 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