{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:36:14Z","timestamp":1789184174033,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,4,8]],"date-time":"2012-04-08T00:00:00Z","timestamp":1333843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It remains unclear whether initial compact lipiodol uptake after transarterial chemoembolisation (<jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content>) is associated with improved survival in patients with hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To reveal the clinical relevance of compact lipiodolisation after <jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 490 patients with unresectable <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> who had first been treated with <jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content>. Compact lipiodolisation was defined as the absence of an arterial enhancing lesion, reflecting complete lipiodol uptake, as assessed by dynamic computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) 1\u00a0month after treatment. The rate of initial compact lipiodolisation was analysed according to multiplicity and size of tumour, and survival of patients who achieved compact lipiodolisation was compared to that of patients who did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 490 patients, 409 (83.5%) were in Child\u2013<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ugh class A and 81 (16.5%) in class B. The rate of initial compact lipiodolisation in single <jats:styled-content style=\"fixed-case\">HCCs<\/jats:styled-content> was higher than that in multinodular <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>s (33.7% vs. 14.6%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Among single <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>s, the rate of compact lipiodolisation in tumours \u22645, 5\u201310 and &gt;10\u00a0cm was 46.6%, 13.6%, and 0% respectively. The 1\u2010, 3\u2010 and 5\u2010year survival rates of patients with compact uptake were 92.7%, 70.7% and 52.4% compared to 60.8%, 28.0% and 16.9% in patients with noncompact lipiodolisation. Multivariate analysis revealed that Child\u2013Pugh class, alpha\u2010fetoprotein level, tumour node metastasis stage, portal vein thrombosis and initial compact lipiodolisation were independent predictors of survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Initial compact lipiodol uptake after transarterial chemoembolisation is associated with improved survival in patients with unresectable hepatocellular carcinoma. Accordingly, initial complete lipiodolisation should be considered a relevant therapeutic target.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05089.x","type":"journal-article","created":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T00:53:45Z","timestamp":1333932825000},"page":"1343-1350","source":"Crossref","is-referenced-by-count":81,"title":["Radiological response predicts survival following transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma"],"prefix":"10.1111","volume":"35","author":[{"given":"D. Y.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. U.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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