{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:52:38Z","timestamp":1769165558002,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T00:00:00Z","timestamp":1333929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>elicobacter<\/jats:italic>\u2010negative gastritis and duodenitis occur more often in patients with inflammatory bowel disease (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>) than in non\u2010<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> controls. Preliminary evidence suggests that they are particularly common among children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study the age\u2010specific occurrence of gastritis and duodenitis among paediatric <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From a computerised database of surgical pathology reports, we selected 344 <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients and 4241 non\u2010<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> controls between the age 0 and 21\u00a0years, who underwent colonoscopy and oesophago\u2010gastro\u2010duodenoscopy with biopsy results from both procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>elicobacter<\/jats:italic>\u2010negative chronic active gastritis was found in 2% of controls and 20% of <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>rohn's disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) 26%, ulcerative colitis (<jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>) 13%). Duodenitis was found in 2% of controls and 17% of <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>rohn's disease 28%, <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> 8%). Similar prevalence rates were observed in male and female patients. The most striking age\u2010specific patterns were seen in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>rohn's disease, with chronic active gastritis being highest in the 5\u20139\u00a0years age\u2010group and declining in all subsequent age\u2010groups. The age\u2010specific rise and fall of duodenitis appeared more protracted, reaching a peak at age 10\u201314\u00a0years and then gradually declining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>elicobacter<\/jats:italic>\u2010negative gastritis and duodenitis occur significantly more often in paediatric <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients than in non\u2010<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> controls, as well as in adult <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients. Such upper gastrointestinal inflammation appears to be particularly common in patients with <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>rohn's disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05090.x","type":"journal-article","created":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T09:55:40Z","timestamp":1333965340000},"page":"1310-1316","source":"Crossref","is-referenced-by-count":34,"title":["Non\u2010<scp><i>H<\/i><\/scp><i>elicobacter pylori<\/i> gastritis is common among paediatric patients with inflammatory bowel disease"],"prefix":"10.1111","volume":"35","author":[{"given":"R. M.","family":"Genta","sequence":"first","affiliation":[{"name":"Miraca Life Sciences Irving TX USA"},{"name":"University of Texas Southwestern Medical Center Dallas TX USA"},{"name":"Dallas VA Medical Center Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sonnenberg","sequence":"additional","affiliation":[{"name":"Portland VA Medical Center Portland OR USA"},{"name":"Oregon Health &amp; Science University Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802647426"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.3.379"},{"key":"e_1_2_6_4_1","first-page":"103","article-title":"Crohn's disease in endoscopic biopsies of the gastric antrum and duodenum","volume":"76","author":"Korelitz BI","year":"1981","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07354.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529708996539"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9041230"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050133"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01851.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(85)80147-3"},{"key":"e_1_2_6_11_1","first-page":"1415","article-title":"Focally enhanced gastritis in children with Crohn's disease and ulcerative colitis","volume":"97","author":"Sharif F","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199804000-00001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01105.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000138182.97366.b4"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21356"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31805563f3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2006.04.001"},{"issue":"2","key":"e_1_2_6_19_1","first-page":"45","article-title":"The incidence of Helicobacter pylori infection","volume":"9","author":"Parsonnet J","year":"1995","journal-title":"Aliment Pharmacol Ther"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21116"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20111"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.06045.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2008.07.006"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2012.05090.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2012.05090.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T05:59:34Z","timestamp":1700546374000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2012.05090.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,9]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1365-2036.2012.05090.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2012.05090.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,9]]}}}