{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:47:18Z","timestamp":1772160438269,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T00:00:00Z","timestamp":1335139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Oesophageal balloon distension test (\n                      <jats:styled-content style=\"fixed-case\">EBDT<\/jats:styled-content>\n                      ) has been advocated for the evaluation of functional oesophageal noncardiac chest pain (\n                      <jats:styled-content style=\"fixed-case\">NCCP<\/jats:styled-content>\n                      ), but its diagnostic utility remains unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To prospectively assess the diagnostic yield of\n                      <jats:styled-content style=\"fixed-case\">EBDT<\/jats:styled-content>\n                      in clinical practice and compare its yield with standard oesophageal tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Over a period of 6\u00a0years, patients with chest pain and negative cardiac work\u2010up underwent sequential testing with endoscopy\/biopsy, oesophageal manometry, 24\u00a0h\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      study and\n                      <jats:styled-content style=\"fixed-case\">EBDT<\/jats:styled-content>\n                      to elucidate an oesophageal source for their symptoms. Patients with a definite abnormality, for example, erosive oesophagitis on oesophagogastroduodenoscopy (\n                      <jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content>\n                      ) were designated as having positive test and excluded from further work up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 348 (m\/f\u00a0=\u00a0105\/243) suspected\n                      <jats:styled-content style=\"fixed-case\">NCCP<\/jats:styled-content>\n                      patients, 16 (5%) were excluded; 332 (95%) underwent oesophageal testing. Among these, 48 (14%) had macro\/microscopic oesophagitis on endoscopy, 7 (2%) had achalasia and 96 (28%) had excessive acid reflux (\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      study). The remaining 181 (52%) patients underwent\n                      <jats:styled-content style=\"fixed-case\">EBDT<\/jats:styled-content>\n                      ; 128 (37%) had oesophageal hypersensitivity. Chest pain was reproduced in 97\/128 (75%) subjects. There were no adverse effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Oesophageal testing can reveal an oesophageal source for chest pain in 86% of\n                      <jats:styled-content style=\"fixed-case\">NCCP<\/jats:styled-content>\n                      subjects. The majority (42%) of patients had gastro\u2010oesophageal reflux disease (\n                      <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>\n                      ). Oesophageal balloon distension test identified hypersensitivity in over one\u2010third of subjects.\n                      <jats:styled-content style=\"fixed-case\">The oesophageal balloon distension test<\/jats:styled-content>\n                      provides useful diagnostic information and should be performed routinely in patients with\n                      <jats:styled-content style=\"fixed-case\">NCCP<\/jats:styled-content>\n                      after excluding\n                      <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05103.x","type":"journal-article","created":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T20:32:26Z","timestamp":1335213146000},"page":"1474-1481","source":"Crossref","is-referenced-by-count":23,"title":["Diagnostic utility of the oesophageal balloon distension test in the evaluation of oesophageal chest pain"],"prefix":"10.1111","volume":"35","author":[{"given":"I.","family":"Nasr","sequence":"first","affiliation":[{"name":"University of Iowa Hospitals and Clinics  Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Attaluri","sequence":"additional","affiliation":[{"name":"University of Iowa Hospitals and Clinics  Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Coss\u2010Adame","sequence":"additional","affiliation":[{"name":"Georgia Health Sciences University  Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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