{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T18:01:42Z","timestamp":1771264902061,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T00:00:00Z","timestamp":1335225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The histological pattern of fibrosis in liver cirrhosis varies in different chronic liver diseases, and hepatic decompensation may be differentiated in consequences of fibrosis (i.e. ascites, variceal bleeding) or in lack of function (i.e. jaundice) resulting in aetiology\u2010specific variable morbidity and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate patterns of hepatic decompensation in relation to the aetiology of liver cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two different cohorts were retrospectively evaluated between 2002 and 2007. Cohort A was for hypothesis generation and consisted of 220 cirrhotic patients. To confirm the initial observations a second cohort B (<jats:italic>n<\/jats:italic>\u00a0=\u00a0217) was analysed. The different patterns of hepatic decompensation evaluated were ascites, jaundice, encephalopathy, variceal bleeding, spontaneous bacterial peritonitis, hepatorenal syndrome or hepatocellular carcinoma.<\/jats:p><jats:p>Furthermore, we analysed survival in relation to pattern of decompensation in alcoholic vs. non\u2010alcoholic liver disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Alcoholics were more frequently hospitalised for ascites (cohort A: 81.4% vs. 65.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.016; cohort B 71.3% vs. 58.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.085). In contrast, non\u2010alcoholics presented with higher rates of hepatocellular carcinoma (cohort A: 23.1% vs. 11.9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.046; cohort B 38.6% vs. 22.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.018). There were no significant differences in jaundice, variceal bleeding, hepatorenal syndrome or encephalopathy.<\/jats:p><jats:p>Survival was significantly impaired in non\u2010alcoholic cirrhosis once ascites occurred (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003), whereas ascites did not predict higher mortality in patients with alcoholic cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ascites is the leading initial pattern of decompensation in alcoholic cirrhosis whereas hepatocellular carcinoma dominates in non\u2010alcoholics. Non\u2010alcoholics developing ascites show a poor survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05108.x","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T03:22:42Z","timestamp":1335324162000},"page":"1443-1450","source":"Crossref","is-referenced-by-count":27,"title":["Different patterns of decompensation in patients with alcoholic vs. non\u2010alcoholic liver cirrhosis"],"prefix":"10.1111","volume":"35","author":[{"given":"J.","family":"Wiegand","sequence":"first","affiliation":[{"name":"Universit\u00e4tsklinikum Leipzig Klinik und Poliklinik f\u00fcr Gastroenterologie und Rheumatologie  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"K\u00fchne","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Leipzig Klinik und Poliklinik f\u00fcr Gastroenterologie und Rheumatologie  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Pradat","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology Hospices Civils de Lyon Hopital de la Croix\u2010Rousse  Lyon France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1  Lyon France"},{"name":"INSERM U1052  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"M\u00f6ssner","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Leipzig Klinik und Poliklinik f\u00fcr Gastroenterologie und Rheumatologie  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Trepo","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology Hospices Civils de Lyon Hopital de la Croix\u2010Rousse  Lyon France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1  Lyon France"},{"name":"INSERM U1052  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. L.","family":"Tillmann","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Leipzig Klinik und Poliklinik f\u00fcr Gastroenterologie und Rheumatologie  Leipzig Germany"},{"name":"Duke Clinical Research Institute Duke University Medical Center  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(02)00531-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.05.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22853"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22273"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040319"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01320309"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03653.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23500"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1267537"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.04.007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05640.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25797"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22906"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23584"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80297-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60383-9"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02071.x"},{"key":"e_1_2_6_21_1","first-page":"486","article-title":"Regional differences in the prevalence of high\u2010risk alcohol drinking: secondary analysis of the East\u2010West health survey","volume":"60","author":"Meyer C","year":"1998","journal-title":"Gesundheitswesen"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-858876"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01132.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.07.023"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22898"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.12.030"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01070.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22694"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23744"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23327"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23246"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.11.040"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520410006350"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2005.01181.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02261.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32832ff35d"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2010.506375"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05851.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21103"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.282.6260.263"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02212706"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04473.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02255.x"}],"container-title":["Alimentary Pharmacology &amp; 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